Background/Aims: Prurigo nodularis (PN) has multiple reported disease associations, and this study analyzes the demographics, clinical distribution and underlying etiologies in an Asian cohort. Methods: A 1-year retrospective study was carried out on PN patients with extensive lesions (≥10) who attended a specialized itch clinic. Results: 37 patients (46% male, median age 53 years) were included. In all patients, an underlying etiologic factor associated with pruritus could be identified. 49% (n = 18) of patients had a single attributable etiology, whilst 51% (n = 19) had multiple etiologies. Among all patients, dermatological disease was the most common cause (82%), of which endogenous eczema comprised the majority of cases (54%), followed by systemic disease (38%). Conclusions: All patients with extensive PN had identifiable factors associated with pruritus in this study, and a dermatological condition was the predominant etiology in both patients with mono- and multifactorial disease. A significant number of patients had underlying systemic causes.
In clinical settings, HIV rapid tests were less sensitive in high-income countries compared with low-income countries, missing about one in seven infections, possibly because of the larger proportion of acute infections in targeted populations. This suggests that in high-income countries, HIV rapid tests should be used in combination with fourth-generation EIA or NAAT tests, except in special circumstances. Prospective Registration of Systematic Reviews registration number CRD42015020154.Supplementary video link: http://links.lww.com/QAD/A924.
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