Plana-Ripoll et al. A comprehensive analysis of mortality-related health metrics associated with mental disorders. 1A comprehensive analysis of mortality-related health metrics associated with mental disorders: a nationwide, register-based cohort study

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Social Security and Medicare actuaries should account for the growing number of beneficiaries with multiple chronic conditions when determining population projections and trust fund solvency.

The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH).

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The remarkable growth in life expectancy during the twentieth century inspired predictions of a future in which all people, not just a fortunate few, will live long lives ending at or near the maximum human life span. We show that increased longevity has been accompanied by less variation in ages at death, but survivors to the oldest ages have grown increasingly heterogeneous in their mortality risks. These trends are consistent across countries, and apply even to populations with record-low variability in the length of life. We argue that as a result of continuing improvements in survival, delayed mortality selection has shifted health disparities from early to later life, where they manifest in the growing inequalities in late-life mortality.

Biodiversity loss is a major challenge. Over the past century, the average rate of vertebrate extinction has been about 100-fold higher than the estimated background rate and population declines continue to increase globally. Birth and death rates determine the pace of population increase or decline, thus driving the expansion or extinction of a species. Design of species conservation policies hence depends on demographic data (e.g., for extinction risk assessments or estimation of harvesting quotas). However, an overview of the accessible data, even for better known taxa, is lacking. Here, we present the Demographic Species Knowledge Index, which classifies the available information for 32,144 (97%) of extant described mammals, birds, reptiles, and amphibians. We show that only 1.3% of the tetrapod species have comprehensive information on birth and death rates. We found no demographic measures, not even crude ones such as maximum life span or typical litter/clutch size, for 65% of threatened tetrapods. More field studies are needed; however, some progress can be made by digitalizing existing knowledge, by imputing data from related species with similar life histories, and by using information from captive populations. We show that data from zoos and aquariums in the Species360 network can significantly improve knowledge for an almost eightfold gain. Assessing the landscape of limited demographic knowledge is essential to prioritize ways to fill data gaps. Such information is urgently needed to implement management strategies to conserve at-risk taxa and to discover new unifying concepts and evolutionary relationships across thousands of tetrapod species.

Mortality estimates for many populations are derived using model life tables, which describe typical age patterns of human mortality. We propose a new system of model life tables as a means of improving the quality and transparency of such estimates. A flexible two-dimensional model was fitted to a collection of life tables from the Human Mortality Database. The model can be used to estimate full life tables given one or two pieces of information: child mortality only, or child and adult mortality. Using life tables from a variety of sources, we have compared the performance of new and old methods. The new model outperforms the Coale-Demeny and UN model life tables. Estimation errors are similar to those produced by the modified Brass logit procedure. The proposed model is better suited to the practical needs of mortality estimation, since both input parameters are continuous yet the second one is optional.