In our present work, we emphasized on the potential of barbituric acid (1) derivatives
as drugs like anti-bacterial, hypnotic, sedative, anti-microbial and antifungal
agents. As naturally occurring, barbituric acid (1) is inactive but in the derivative form, it
has a large number of medicinal uses and nowadays, it has a great demand in the pharmaceutical
industry. Barbituric acid has a wide range of applications in the synthesis of a diverse
class of compounds like heterocyclic, carbocyclic, synthetic alkaloids, and due to its
broad-spectrum applications, barbituric acid acquired the position of building blocks in
synthetic chemistry. Through the history of humanity, a number of bioactive agents have
been applied to cure the disease related to hypnotics and sedatives, while the exact efficacy
of these agents was found to be limited. Till now, review articles on barbituric acid
only express their specific aspect but in present review article, all aspects are discussed in detail to provide a
platform to readers and researchers so that they could obtain all information and background knowledge from a
single point.
Objective: To determine the frequency of electrolyte disorders, i.e., serum sodium and potassium and to evaluate its effect on mortality rate among children admitted at the pediatric intensive care unit. Study Design and Setting: This was a descriptive cross sectional study conducted at Pediatric Intensive care unit of Civil Hospital Karachi from April to December 2017 Methodology: Informed consent was obtained from 150 parents of the children who fulfill the inclusion criteria. Laboratory data (serum sodium and serum potassium) were recorded during the stay in the pediatric intensive care unit. Data was analyzed using SPSS version 20. Mean ± S.D was calculated for quantitative variables. Frequency and percentage were calculated for gender, electrolyte disorders and mortality. Effect modifiers were controlled by stratification of age, gender and electrolyte disorders (Hypernatremia, Hyponatremia, Hyperkalemia, and Hypokalemia). Post-stratification, Chi-squared test was applied. P-value = 0.05 was taken as significant. Results: Out of 150 patients, electrolyte disorders in terms of serum sodium and potassium, were found in 86(57.3%) children. Mortality in children with electrolyte disorders was found to be 46(53.5%) which was significantly higher (P<0.001) than patients without electrolyte disorders 40(46.5%). Hypernatremia was found in 48(32%), hyponatremia 24(16%), hyperkalemia 21(14%) and hypokalemia in 42(28%) patients.In comparison; of electrolyte disorders with mortality; significant association was found in hypernatremia (P<0.001), and hyperkalemia (P<0.001). Conclusion: The most common electrolyte abnormalities were hypernatremia and hypokalemia. Mortality was significantly higher in subjects with electrolyte disorders, especially hypernatremia and hyperkalemia
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