Angular distributions of the decay B 0 → K * 0 µ + µ − are studied using a sample of proton-proton collisions at √ s = 8 TeV collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 20.5 fb −1 . An angular analysis is performed to determine the P 1 and P 5 parameters, where the P 5 parameter is of particular interest because of recent measurements that indicate a potential discrepancy with the standard model predictions. Based on a sample of 1397 signal events, the P 1 and P 5 parameters are determined as a function of the dimuon invariant mass squared. The measurements are in agreement with predictions based on the standard model.
The first observation of the Z boson decaying to four leptons in proton-proton collisions is presented. The analyzed data set corresponds to an integrated luminosity of 5.02 fb −1 at √ s = 7 TeV collected by the CMS detector at the Large Hadron Collider. A pronounced resonance peak, with a statistical significance of 9.7 σ, is observed in the distribution of the invariant mass of four leptons (electrons and/or muons) with mass and width consistent with expectations for Z boson decays. The branching fraction and cross section reported here are defined by phase space restrictions on the leptons, namely, 80 < m 4 < 100 GeV, where m 4 is the invariant mass of the four leptons, and m > 4 GeV for all pairs of leptons, where m is the two-lepton invariant mass. The measured branching fraction is B(Z → 4 ) = 4.2
Type 1 diabetic patients with varying severity of kidney disease were investigated to create multimetabolite models of the disease process. Urinary albumin excretion rate was measured for 3358 patients with type 1 diabetes. Prospective records were available for 1051 patients, of whom 163 showed progression of albuminuria (8.3-year follow-up), and 162 were selected as stable controls. At baseline, serum lipids, lipoprotein subclasses, and low-molecular weight metabolites were quantified by NMR spectroscopy (325 samples). The data were analyzed by the self-organizing map. In cross-sectional analyses, patients with no complications had low serum lipids, less inflammation, and better glycemic control, whereas patients with advanced kidney disease had high serum cystatin-C and sphingomyelin. These phenotype extremes shared low unsaturated fatty acids (UFAs) and phospholipids. Prospectively, progressive albuminuria was associated with high UFAs, phospholipids, and IDL and LDL lipids. Progression at longer duration was associated with high HDL lipids, whereas earlier progression was associated with poor glycemic control, increased saturated fatty acids (SFAs), and inflammation. Diabetic kidney disease consists of diverse metabolic phenotypes: UFAs, phospholipids, IDL, and LDL may be important in the subclinical phase, high SFAs and low HDL suggest accelerated progression, and the sphingolipid pathway in advanced kidney injury deserves further research.
Diabetic kidney disease, diagnosed by urinary albumin excretion rate (AER), is a critical symptom of chronic vascular injury in diabetes, and is associated with dyslipidemia and increased mortality. We investigated serum lipids in 326 subjects with type 1 diabetes: 56% of patients had normal AER, 17% had microalbuminuria (20 ≤ AER < 200 μg/min or 30 ≤ AER < 300 mg/24 h) and 26% had overt kidney disease (macroalbuminuria AER ≥ 200 μg/min or AER ≥ 300 mg/24 h). Lipoprotein subclass lipids and low-molecular-weight metabolites were quantified from native serum, and individual lipid species from the lipid extract of the native sample, using a proton NMR metabonomics platform. Sphingomyelin (odds ratio 2.53, P < 10−7), large VLDL cholesterol (odds ratio 2.36, P < 10−10), total triglycerides (odds ratio 1.88, P < 10−6), omega-9 and saturated fatty acids (odds ratio 1.82, P < 10−5), glucose disposal rate (odds ratio 0.44, P < 10−9), large HDL cholesterol (odds ratio 0.39, P < 10−9) and glomerular filtration rate (odds ratio 0.19, P < 10−10) were associated with kidney disease. No associations were found for polyunsaturated fatty acids or phospholipids. Sphingomyelin was a significant regressor of urinary albumin (P < 0.0001) in multivariate analysis with kidney function, glycemic control, body mass, blood pressure, triglycerides and HDL cholesterol. Kidney injury, sphingolipids and excess fatty acids have been linked in animal models—our exploratory approach provides independent support for this relationship in human patients with diabetes.Electronic supplementary materialThe online version of this article (doi:10.1007/s11306-011-0343-y) contains supplementary material, which is available to authorized users.
The W boson helicity fractions from top quark decays in tt events are measured using data from proton-proton collisions at a centre-of-mass energy of 8 TeV. The data were collected in 2012 with the CMS detector at the LHC, corresponding to an integrated luminosity of 19.8 fb −1 . Events are reconstructed with either one muon or one electron, along with four jets in the final state, with two of the jets being identified as originating from b quarks. The measured helicity fractions from both channels are combined, yielding F 0 = 0.681 ± 0.012 (stat) ± 0.023 (syst), F L = 0.323 ± 0.008 (stat) ± 0.014 (syst), and F R = −0.004 ± 0.005 (stat) ± 0.014 (syst) for the longitudinal, left-, and right-handed components of the helicity, respectively. These measurements of the W boson helicity fractions are the most accurate to date and they agree with the predictions from the standard model.
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