International audienceIn spite of a great number of industrial applications, the thermal design of contact dryers for sewage sludge remains empirical. To improve the understanding of drying mechanisms, the penetration theory developed by Schlünder and co-workers for mono and multi dispersed packing is used to represent the experimental results from a laboratory scale dryer. For granular packing, the only adjustment parameter of the model is the mixing number, which characterizes the dryer and its stirrer. For pasty-like materials, the pasty phase is assumed to be a saturated particulate phase. As the calculation of the effective properties calculation is cumbersome for a multi-granular packing, the particulate phase is considered as a mono-dispersed packing, whose dimension is unknown. To identify the two adjustment parameters, the mixing number was quantified from experiments performed on activated alumina balls, for which physical and thermal characteristics are known, and then the characteristic dimension of the sludge was determined by adjustment of experimental drying kinetics measured in a batch agitated dryer. According to this model, drying is exclusively controlled by the contact resistance between the wall and the biggest particles contained in the dewatered sludge. The model allows to find most of the tendencies experimentally observed for different operating conditions

a b s t r a c tThis study aims at better understanding the wet granulation process of a binary mixture composed of microcrystalline cellulose (water insoluble) and lactose (water soluble). It investigates the effect of formulation (proportion of the different components in the mixture) on the granule growth kinetics, the evolution of granule morphology during granulation, the wet mass consistency and dry granule strength of the end product. Additionally the influence of mixer design has been studied by up scaling the process from the 1.9 L Mi-pro high shear mixer used as the reference scale to a 6 L Diosna P1-6 high shear mixer. The scale-up rules investigated were constant impeller tip speed and constant Froude number. Our results allowed us to draw the following conclusions: -The increase in MCC content is found to increase the optimum binder requirement for granulation, wet mass consistency and dry granule strength.-Granule growth takes place in three distinct stages: wetting, nucleation and growth. These stages can be identified with the help of the recorded torque values during the granulation process or by the evolution of granule size and granule morphology.-The characterization of the starting materials by moisture sorption isotherms brings more insight to the role of each component during the granulation process.-The increase of the granulation scale has little influence on the observed growth mechanism. However bimodality of the granule size distribution is increased, wet mass consistency and dry granule strength are decreased with increasing scale of operation.

The effect of the main means of agitation in a high shear mixer has been investigated in this study. Granulation runs have been performed on a fine cohesive microcrystalline cellulose powder (Avicel 105, d 50 = 20 μm) often used as a pharmaceutical excipient in tablet formulations in two bowls of a Mi-Pro® laboratory high shear mixer with a capacity of 0.9 and 1.9 L, respectively. Torque curves recorded during granulation are found to allow good control of the process while increasing impeller speed is found to generally reduce granule size and the onset of breakage seems to occur for similar values of impeller tip speed. As a general rule, the chopper allows for better binder distribution in the Mi-Pro® and is found to be necessary for successful granulation at low to moderate impeller speeds. For high impeller speeds in excess of 4.4 m/s with or without a chopper, similar granule sizes and growth mechanisms are observed. Granule roundness was found to increase with impeller speed up to a certain speed after which granule roundness has been found to decrease with increasing impeller speed most probably because of increased breakage of the granules. Dry granule strength has been found to increase with increasing impeller speed, presenting only a slight decrease at the highest impeller speed studied.