Fast radio bursts (FRBs) are bright, millisecond-duration radio transients originating from extragalactic distances 1 . Their origin is unknown. Some FRB sources emit repeat bursts, ruling out cataclysmic origins for those events [2][3][4] . Despite searches for periodicity in repeat burst arrival times on time scales from milliseconds to many days 2, 5-7 , these bursts have hitherto been observed to appear sporadically, and though clustered 8 , without a regular pattern. Here we report the detection of a 16.35 ± 0.18 day periodicity from a repeating FRB 180916.J0158+65 detected by the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst Project (CHIME/FRB) 4, 9 . In 28 bursts recorded from 16th September 2018 through 30th October 2019, we find that bursts arrive in a 4.0-day phase window, with some cycles showing no bursts, and some showing multiple bursts, within CHIME's limited daily exposure. Our results suggest a mechanism for periodic modulation either of the burst emission itself, or through external amplification or absorption, and disfavour models invoking purely sporadic processes.Last year the CHIME/FRB collaboration reported the discovery of eight new repeating FRB sources 4 , including FRB 180916.J0158+65, which was recently localized to a star-forming region in a nearby massive spiral galaxy at redshift 0.0337±0.0002 10 . From September 2018 to November 2019, CHIME/FRB has detected a total of 28 bursts from FRB 180916.J0158+65, which remains the most active source from this recent CHIME/FRB repeater sample. The barycentric arrival times for the 28 bursts (including those has been published before) from FRB 180916.J0158+65, corrected for delays from pulse dispersion, are listed in Extended Data Table 1.To search for periodicity, the burst arrival times (spanning a 400-day time range) were folded with different periods from 1.57 to 62.8 days (see Methods), with a Pearson's χ 2 test applied to each resulting profile with 8 phase bins 11 . A reduced χ 2 1 with respect to a uniform distribution indicates a periodicity unlikely to arise by chance. Furthermore, to account for the possible non-Poissonian statistics of the bursts 12 , we have applied the search with different weighting schemes that consider clustered bursts of different time range to be correlated events (see Methods).Searches with different weightings return periodograms of similar shape and have the same primary peak with significance varying between 3.5 − 8σ. As an example, the reduced χ 2 versus period using a weighting that counts only active days instead of individual events is shown in Figure 1a. A distinct peak is detected at 16.35 ± 0.18 days, with

We present a catalog of 536 fast radio bursts (FRBs) detected by the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst (CHIME/FRB) Project between 400 and 800 MHz from 2018 July 25 to 2019 July 1, including 62 bursts from 18 previously reported repeating sources. The catalog represents the first large sample, including bursts from repeaters and nonrepeaters, observed in a single survey with uniform selection effects. This facilitates comparative and absolute studies of the FRB population. We show that repeaters and apparent nonrepeaters have sky locations and dispersion measures (DMs) that are consistent with being drawn from the same distribution. However, bursts from repeating sources differ from apparent nonrepeaters in intrinsic temporal width and spectral bandwidth. Through injection of simulated events into our detection pipeline, we perform an absolute calibration of selection effects to account for systematic biases. We find evidence for a population of FRBs—composing a large fraction of the overall population—with a scattering time at 600 MHz in excess of 10 ms, of which only a small fraction are observed by CHIME/FRB. We infer a power-law index for the cumulative fluence distribution of α = − 1.40 ± 0.11 ( stat. ) − 0.09 + 0.06 ( sys. ) , consistent with the −3/2 expectation for a nonevolving population in Euclidean space. We find that α is steeper for high-DM events and shallower for low-DM events, which is what would be expected when DM is correlated with distance. We infer a sky rate of [ 820 ± 60 ( stat. ) − 200 + 220 ( sys. ) ] / sky / day above a fluence of 5 Jy ms at 600 MHz, with a scattering time at 600 MHz under 10 ms and DM above 100 pc cm−3.

Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circulating CD8+ T-cell profiles from patients hospitalized with avian H7N9, seasonal IAV, and influenza vaccinees. Patient survival reflects an early, transient prevalence of highly activated CD38+HLA-DR+PD-1+ CD8+ T cells, whereas the prolonged persistence of this set is found in ultimately fatal cases. Single-cell T cell receptor (TCR)-αβ analyses of activated CD38+HLA-DR+CD8+ T cells show similar TCRαβ diversity but differential clonal expansion kinetics in surviving and fatal H7N9 patients. Delayed clonal expansion associated with an early dichotomy at a transcriptome level (as detected by single-cell RNAseq) is found in CD38+HLA-DR+CD8+ T cells from patients who succumbed to the disease, suggesting a divergent differentiation pathway of CD38+HLA-DR+CD8+ T cells from the outset during fatal disease. Our study proposes that effective expansion of cross-reactive influenza-specific TCRαβ clonotypes with appropriate transcriptome signatures is needed for early protection against severe influenza disease.

We present a Radio Recombination Line (RRL) survey of the Galactic Plane from the Hi Parkes All-sky Survey and associated Zone of Avoidance survey, which mapped the region l = 196 • -0 • -52 • and |b| 5 • at 1.4 GHz and 14.4 arcmin resolution. We combine three RRLs, H168α, H167α, and H166α to derive fully sampled maps of the diffuse ionized emission along the inner Galactic plane. The velocity information, at a resolution of 20 km s −1 , allows us to study the spatial distribution of the ionized gas and compare it with that of the molecular gas, as traced by CO. The longitudevelocity diagram shows that the RRL emission is mostly associated with CO gas from the molecular ring and is concentrated within the inner 30 • of longitude. A map of the free-free emission in this region of the Galaxy is derived from the line-integrated RRL emission, assuming an electron temperature gradient with Galactocentric radius of 496 ± 100 K kpc −1 . Based on the thermal continuum map we extracted a catalogue of 317 compact ( < ∼ 15 arcmin) sources, with flux densities, sizes and velocities. We report the first RRL observations of the southern ionized lobe in the Galactic centre. The line profiles and velocities suggest that this degree-scale structure is in rotation. We also present new evidence of diffuse ionized gas in the 3-kpc arm. Helium and carbon RRLs are detected in this survey. The He line is mostly observed towards Hii regions, whereas the C line is also detected further away from the source of ionization. These data represent the first observations of diffuse C RRLs in the Galactic plane at a frequency of 1.4 GHz.