Carbapenem-resistant K. pneumoniae (CR-Kp) is an emerging multi-drug resistant nosocomial pathogen. This is a retrospective chart review describing the outcomes and treatment of 60 cases of CR-Kp bloodstream infections. All CR-Kp isolated from blood cultures were identified retrospectively from the microbiology laboratory from January 2007 to May 2009. Clinical information was collected from the electronic medical record. Patients with 14 day-hospital mortality were compared to those who survived 14 days. The all-cause in-hospital and 14-day mortality for all 60 CR-Kp bloodstream infections was 58.3% and 41.7%, respectively. In this collection, 98% of tested isolates were susceptible in vitro to tigecycline, compared to 86% to colistimethate, 45% to amikacin and 22% to gentamicin. Nine patients died prior to cultures being finalized, and received no therapy active against CR-Kp. In the remaining 51 patients, those who survived to day14 (n=35) were compared to non-survivor at day 14 (n=16). These patients were * Corresponding Author: David van Duin, MD, PhD, Department of Infectious Diseases, Mailcode G21, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, vanduid@ccf.org. Alternate Author to receive proofs: Elizabeth Neuner, PharmD. Pharmacy, JJN1-02, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, neunere@ccf.org Potential Conflicts of Interest: DvD is a member of the speakers' bureaus for Pfizer Inc. and Astellas Pharmaceuticals, and has served on the advisory board for Pfizer Inc. RAB has received research funding from Pfizer Inc.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. . However, the low plasma concentrations of tigecycline and the toxicity associated with colistimethate make these less appealing options for use in BSI. In addition to these concerns, the published outcome data for these two agents in the treatment of CR-Kp BSI are limited. The aim of this study was to describe the treatment and outcomes of CR-Kp BSI in a single large tertiary care center.
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Methods
Study Location and DesignThe study was conducted at Cleveland Clinic, a 1400 bed academic medical center in Cleveland, Ohio. This was a non-interventional, retrospective chart review of CR-Kp BSI from January 2007 to May 2009. This study was approved by the Cleveland Clinic Institutional Review Board.
Microbiologic MethodsAutomated systems were used to process blood cultures (BacTAlert®) and for identification of K. pneumoniae isolates (Vitek 2). Antimicrobial susceptibility testing (AST) was performed using the automated broth microdilution system (V...