In infants with fluctuations in Spo(2), automated Fio(2) adjustment improved maintenance of the intended Spo(2) range led to reduced time with high Spo(2) and more-frequent episodes with Spo(2) between 80% and 86%.

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HFOV increases mortality for most patients with ARDS but may improve survival among patients with severe hypoxemia on conventional mechanical ventilation.

During oxygen therapy, preterm infants spent more time within the SpO target range after implementation of automated oxygen control, with a significant reduction in hyperoxaemia, but not hypoxaemia.