Electrospun technology becomes a valuable means of fabricating functional polymeric nanofibers with distinctive morphological properties for drug delivery applications. Nanofibers are prepared from the polymer solution, which allows the direct incorporation of therapeutics such as small drug molecules, genes, and proteins by merely mixing them into the polymeric solution. Due to their biocompatibility, adhesiveness, sterility, and efficiency in delivering diverse cargoes, electrospun nanofibers have gained much attention. This review discusses the capabilities of the electrospun nanofibers in delivering different therapeutics like small molecules, genes, and proteins to their desired target site for treating various ailments. The potential of nanofibers in administering through multiple administration routes and the associated challenges has also been expounded along with a cross‐talk about the commercial products of nanofibers for biomedical applications.
This paper introduces a real-time neighbour scoring system, using data collected from various web-based APIs, to facilitate "15-minute city" designs. The system extends on the current state of the art in three ways; first, it incorporates a multi-source urban API, to automate the extraction of location-based information from online sources; second, it provides a quantitative method to calculate and index "15-minute city" performance; and third, it provides a web-based application, to allow real-time feedback of neighbourhood design performance complementing the design refinements at a building and tenancy level. In addition to discussing its theoretical basis, and technical implementation, this paper provides a case study to demonstrate how the neighbourhood scoring system is incorporated into the design of a hypothetical mixed-use urban development.
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