Highlights d RAISIN RNA-seq of 1.6 million cells and 6,513 enteric neurons from adult mice and humans d Dozens of neuron subsets that vary by location, circadian phase, age, and species d Putative interactions between neurons and epithelial, stromal, and immune cells d Enteric neurons express risk genes for extraintestinal diseases with gut dysmotility

Highlights d Mechanisms of inflammatory adverse events induced by checkpoint blockade d Colitis-associated differentiation of CD8 Trm cells to cytotoxic effector cells d Persistence and expansion of CTLA-4 + Treg cells

Highlights d A scRNA-seq study reveals shared and distinct features of human MMRd and MMRp CRC d Co-variation of single-cell transcriptional programs across specimens predicts immune hubs d A myeloid-rich inflammatory hub is identified below the colonic lumen in human CRC d CXCR3-ligand+ cells form foci with activated T cells in human MMRd CRC

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