Detecting various types of cells in and aroundthe tumor matrix holds a special significance in characterizing the tumor micro-environment for cancer prognostication and research. Automating the tasks of detecting, segmenting, and classifying nuclei can free up the pathologists' time for higher value tasks and reduce errors due to fatigue and subjectivity. To encourage the computer vision research community to develop and test algorithms for these tasks, we prepared a large and diverse dataset of nucleus boundary annotations and class labels. The dataset has over 46,000 nuclei from 37 hospitals, 71 patients, four organs, and four nucleus types. We also organized a challenge around this dataset as a satellite event at the International Symposium on Biomedical Imaging (ISBI) in April 2020. The challenge saw a wide participation from across the world, and the top methods were able to match inter-human concordance for the challenge metric. In this paper, we summarize the dataset and the key findings of the challenge, including the commonalities and differences between the methods developed by various participants. We have released the MoNuSAC2020 dataset to the public.
Bone scintigraphy is an effective method to diagnose bone diseases such as bone tumors. In the scintigraphic images, bone abnormalities are widely scattered on the whole body. Conventionally, radiologists visually check the whole-body images and find the distributed abnormalities based on their expertise. This manual process is time-consuming and it is not unusual to miss some abnormalities. In this paper, a computer-aided diagnosis (CAD) system is proposed to assist radiologists in the diagnosis of bone scintigraphy. The system will provide warning marks and abnormal scores on some locations of the images to direct radiologists' attention toward these locations. A fuzzy system called characteristic-point-based fuzzy inference system (CPFIS) is employed to implement the diagnosis system and three minimizations are used to systematically train the CPFIS. Asymmetry and brightness are chosen as the two inputs to the CPFIS according to radiologists' knowledge. The resulting CAD system is of a small-sized rule base such that the resulting fuzzy rules can be not only easily understood by radiologists, but also matched to and compared with their expert knowledge. The prototype CAD system was tested on 82 abnormal images and 27 normal images. We employed free-response receiver operating characteristics method with the mean number of false positives (FPs) and the sensitivity as performance indexes to evaluate the proposed system. The sensitivity is 91.5% (227 of 248) and the mean number of FPs is 37.3 per image. The high sensitivity and moderate numbers of FP marks per image shows that the proposed method can provide an effective second-reader information to radiologists in the diagnosis of bone scintigraphy.
In this study, a millimeter-wave (MMW) radar and an onboard camera are used to develop a sensor fusion algorithm for a forward collision warning system. This study proposed integrating an MMW radar and camera to compensate for the deficiencies caused by relying on a single sensor and to improve frontal object detection rates. Density-based spatial clustering of applications with noise and particle filter algorithms are used in the radar-based object detection system to remove non-object noise and track the target object. Meanwhile, the two-stage vision recognition system can detect and recognize the objects in front of a vehicle. The detected objects include pedestrians, motorcycles, and cars. The spatial alignment uses a radial basis function neural network to learn the conversion relationship between the distance information of the MMW radar and the coordinate information in the image. Then a neural network is utilized for object matching. The sensor with a higher confidence index is selected as the system output. Finally, three kinds of scenario conditions (daytime, nighttime, and rainy-day) were designed to test the performance of the proposed method. The detection rates and the false alarm rates of proposed system were approximately 90.5% and 0.6%, respectively.
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