reviewing the purpose/goal and objectives, and completing the online Examination and Learner Evaluation at http:// www.aornj ournal.org/conte nt/cme. A score of 70% correct on the examination is required for credit. Participants receive feedback on incorrect answers. Each applicant who successfully completes this program can immediately print a certificate of completion. Event: #20505 Session: #0001 Fee: Free for AORN members. For non-member pricing, please visit http://www.aornj ournal.org/conte nt/cme. The contact hours for this article expire February 28, 2023. Nonmember pricing is subject to change. PURPOSE/GOALTo provide the learner with knowledge of best practices related to the management of perioperative thirst. OBJECTIVES 1. Discuss the incidence and etiology of perioperative thirst. 2. Identify key factors related to mitigating perioperative thirst. 3. Describe safety factors affecting the management of perioperative thirst.
Objetivo: Avaliar a prevalência, a intensidade e o desconforto da sede no período pós-operatório imediato. Método: Estudo epidemiológico, transversal, descritivo, quantitativo, realizado em um hospital universitário do Sul do Brasil, de agosto a setembro de 2012. A amostra foi composta de 386 pacientes em recuperação anestésica de cirurgias eletivas e de urgência. Foi utilizado um questionário semiestruturado composto de dados demográficos, clínicos e variáveis relacionadas à sede. Resultados: A prevalência de sede foi de 78% (303 pacientes), com intensidade média de 6,94 (desvio padrão — DP=2,2) e queixa espontânea de sede em 38,3% dos casos (116 pacientes). Os desconfortos relatados foram: boca seca, procura por água, hipossalivação, garganta seca, lábios ressecados, língua seca e vontade de deglutir. Todos os desconfortos apresentaram correlação de Pearson positiva em relação à presença de sede. Conclusão: A sede no pós-operatório imediato é intensa, prevalente e com sinais periféricos desconfortáveis. Essas evidências fundamentam a necessidade da identificação, da mensuração, da avaliação e do tratamento do sintoma sede de forma intencional neste período
Atrial fibrillation (AF) is prevalent in patients with obesity and diabetes, and such patients often exhibit cardiac steatosis. Since the role of cardiac steatosis per se in the induction of AF has not been elucidated, the present study was designed to explore the relation between cardiac steatosis and AF. Transgenic (Tg) mice with cardiac-specific overexpression of perilipin 2 (PLIN2) were housed in the laboratory for more than 12 mo before the study. Electron microscopy of the atria of PLIN2-Tg mice showed accumulation of small lipid droplets around mitochondrial chains, and five- to ninefold greater atrial triacylglycerol (TAG) content compared with wild-type (WT) mice. Electrocardiography showed significantly longer RR intervals in PLIN2-Tg mice than in WT mice. Transesophageal electrical burst pacing resulted in significantly higher prevalence of sustained (>5 min) AF (69%) in PLIN2-Tg mice than in WT mice (24%), although it was comparable in younger (4-mo-old) mice. Connexin 43 (Cx43), a gap junction protein, was localized at the intercalated disks in WT atria but was heterogeneously distributed on the lateral side of cardiomyocytes in PLIN2-Tg atria. Langendorff-perfused hearts using the optical mapping technique showed slower and heterogeneous impulse propagation in PLIN2-Tg atria compared with WT atria. Cardiac overexpression of hormone-sensitive lipase in PLIN2-Tg mice resulted in atrial TAG depletion and amelioration of AF susceptibility. The results suggest that PLIN2-induced steatosis is associated with Cx43 remodeling, impaired conduction propagation, and higher incidence of AF in aged mice. Therapies targeting cardiac steatosis could be potentially beneficial against AF in patients with obesity or diabetes.
Recent genome-wide association studies have identified multiple variants that confer risk of type 2 diabetes mellitus (DM). However, established associations explain only a part of the heritability. Thus, even at the genome-wide association studies era, candidate gene approach should be still useful. Recent interventional studies against the renin-angiotensin system (RAS) showed reduction in new onset of DM, implying the system is involved in the onset. We substantiated the hypothesis that genetic variants of RAS have significant association with prevalence of DM. We enrolled to the study consecutive 782 subjects who had consulted our hospitals for mainly lifestyle related diseases. They consisted of 282 (36.1 %) diabetes cases. Genotypes were assayed with genomic DNA for conventional four genes of the RAS, i.e., angiotensin converting enzyme (ACE) insertion/deletion variant, angiotensinogen (AGT) M235T variant, angiotensin II type I receptor (AT1) A1166C variant, and aldosterone synthase (CYP11B2) C-344T variant. Association between the genetic variants of the RAS and prevalence of type 2 DM was tested. A significant association of DM and CYP11B2 genotype was obtained. There was no significant association between DM and ACE, AGT and AT1 variants. A multivariate logistic regression showed that age, gender, and CYP11B2 genotype were independent factors for association to diabetes, the DM risk of CC/CT to TT being 1.40 (95 % CI 1.04–1.90, p = 0.029). Thus, it is concluded that a genetic variant of the RAS should have a modest but significant impact on the onset of type 2 diabetes mellitus.
<p>Objetivo: avaliar o tempo de jejum pré-operatório, presença e intensidade da sede no pós-operatório imediato. Método: pesquisa documental, quantitativa, descritiva, realizada em 2018, em hospital escola, com amostra de 749 pacientes. Resultados: o tempo médio de jejum absoluto foi de 15:00 (DP 6:30). Pacientes cirúrgicos da urologia apresentaram maior tempo de jejum (16:56; DP 9:09). Em relação à faixa etária, o tempo de jejum variou de 13:29 (DP 7:34) para crianças, a 15:06 (DP 6:32) em adultos e 15:41 (DP 4:37) em idosos. A sede foi um desconforto presente em 84,5% dos pacientes, com intensidade média de 6,54 (DP 2,39) no pós-operatório. Houve associação significativa entre tempo de jejum e presença de sede. A maioria dos pacientes (85,4%) não se queixou de sede espontaneamente. Conclusão: o tempo de jejum pré-operatório foi maior do que o preconizado, independente da clínica cirúrgica ou faixa etária. Os idosos apresentaram maior tempo médio de jejum. <br />Descritores: Jejum. Sede. Enfermagem Perioperatória.</p>
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.