A b s t r a c t -2,5,8(1H)-Quinolineuiones (12), 2,5,6(1H)-quinolineuiones (13), 2-alkoxy-5,8-quinolinediones (14). 2.8-dimethoxy-5,6-quinolinedione (15). and 2,6-dimethoxy-7,8-quinolinediones (16) were synthesized by oxidative demethylation of the corresponding 2(1H)-quinolinones (7) and Zalkoxyquinolines (11) with cerium (IV) ammonium nimte.Streptonigrin (I), a highly substituted 5.8-quinolinedione, was first reported as an antitumor antibiotic produced by Streptomycesflocculus.l It was later found to be one of the most potent inhibitors of avian myeloblastosis virus reverse transcriptase (AMV-RT), but its remarkable cytotoxic activity seemed to be disadvantageous with respect to a specific inhibitor of retroviru~.~ Recently, we observed that synthetic 6-methoxy-5,8-quinoline-
We report the usefulness of revision balloon kyphoplasty (re-BKP) and vertebra-pediculoplasty using cannulated screws (VPCS) for osteoporotic vertebral fractures (OVF) following cement dislodgement of conventional BKP. Between 2015 and 2020, three patients with OVF developed symptomatic cement dislodgement following BKP and underwent re-BKP. All three patients showed a loose cemented mass and spinal instability. Balloon inflation was performed in the gap between the loosened cemented mass and the remaining cortical bone rim, and this extended gap was filled with cement. To prevent re-dislodgement of the cement mass, a cannulated screw was inserted into the cemented mass through the pedicle. All patients achieved early pain relief, and improved vertebral stability of the fractured vertebra and all related symptoms, with no perioperative complications. Re-BKP and VPCS are innovative concepts and could be an effective minimally invasive treatment for OVF following cement dislodgement of conventional BKP treatment.
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