Passive seismic low-frequency ͑from approximately 1-6 Hz͒ data have been acquired at several locations around the world. Spectra calculated from these data, acquired over fields with known hydrocarbon accumulations, show common spectral anomalies. Verification of whether these anomalies are common to only a few, many, or all hydrocarbon reservoirs can be provided only if more and detailed results are reported. An extensive survey was carried out above a tight gas reservoir and an adjacent exploration area in Mexico. Data from several hundred stations with three-component broadband seismometers distributed over approximately 200 km 2 were used for the analysis. Several hydrocarbon reservoir-related microtremor attributes were calculated, and mapped attributes were compared with known gas intervals, with good agreement. Wells drilled after the survey confirm a predicted high hydrocarbon potential in the exploration area. A preliminary model was developed to explain the source mechanism of those microtremors. Poroelastic effects caused by wave-induced fluid flow and oscillations of different fluid phases are significant processes in the low-frequency range that can modify the omnipresent seismic background spectrum. These processes only occur in partially saturated rocks. We assume that hydrocarbon reservoirs are partially saturated, whereas the surrounding rocks are fully saturated. Our real data observations are consistent with this conceptual model.

Biohybrid bacteria–based microrobots are increasingly recognized as promising externally controllable vehicles for targeted cancer therapy. Magnetic fields in particular have been used as a safe means to transfer energy and direct their motion. Thus far, the magnetic control strategies used in this context rely on poorly scalable magnetic field gradients, require active position feedback, or are ill-suited to diffuse distributions within the body. Here, we present a magnetic torque–driven control scheme for enhanced transport through biological barriers that complements the innate taxis toward tumor cores exhibited by a range of bacteria, shown for Magnetospirillum magneticum as a magnetically responsive model organism. This hybrid control strategy is readily scalable, independent of position feedback, and applicable to bacterial microrobots dispersed by the circulatory system. We observed a fourfold increase in translocation of magnetically responsive bacteria across a model of the vascular endothelium and found that the primary mechanism driving increased transport is torque-driven surface exploration at the cell interface. Using spheroids as a three-dimensional tumor model, fluorescently labeled bacteria colonized their core regions with up to 21-fold higher signal in samples exposed to rotating magnetic fields. In addition to enhanced transport, we demonstrated that our control scheme offers further advantages, including the possibility for closed-loop optimization based on inductive detection, as well as spatially selective actuation to reduce off-target effects. Last, after systemic intravenous injection in mice, we showed significantly increased bacterial tumor accumulation, supporting the feasibility of deploying this control scheme clinically for magnetically responsive biohybrid microrobots.

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