Neonicotinoids are currently meaningful component of rotation schemes of insecticides of selective action in the system of integrated pest control, which have agricultural importance in many countries. The research results of the biological impact of acetamiprid (neonicotinoids) on the body of laboratory animals are given in the article. The study showed that the explored active substance is related to the moderately hazardous compounds (hazard category 3) in case of one-time per oral penetration. Acetamiprid has polytropic action in the case of chronic (12 months) oral entering the body of laboratory animals, it gives rise changes in functionality of the central nervous system, blood system, liver functioning. On the base of alterations of the studied indices there were established both the no-effect dose level (NOEL) and acceptable daily intake of acetamiprid for humans.
For the assurance of the safe regulations for the use in agriculture persistent in soil insecticide neonicotinoids derivative, studies have been executed to investigate its impact on the soil microbiocenosis and migration to the neighboring environment of the active ingredient of this pesticide and the preparation based on it. On the ground of obtained experimental data there were determined threshold doses for the following indices of the harmfulness: migration-water, translocation (transmission into plants) and general sanitary indices. There were established limiting indices of the harmfulness: translocation and migration-water indices. The maximum permissible concentration (MPC) of neonicotinoids derivative in the soil accounted for 0.5 mg/kg of the soil. This content of the pesticide in the soil prevents its accumulation in plants in concentrations exceeding the maximum permissible levels (MPLs), in food products, it fails both to give rise in its transition in groundwater above the MPL for water reservoirs and influence on the soil microbiocenosis and self-purification processes.
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