Background The coronavirus infection (COVID-19) pandemic has seen a progressive increase in childhood morbidity worldwide. Continuous mutation of the SARS-CoV-2 virus causes the wave-like course of the COVID-19 pandemic, which is characterized by an undulating course and the predominance of different variants of the SARS-CoV-2 virus. There are many reports that the clinical picture may vary depending on the circulating strain of the virus [7–11, 13–16]. Based on this, we decided to analyze and evaluate the presence of a pattern between the clinical and epidemic COVID-19 characteristics and the strain of the SARS-CoV-2 virus prevailing locally. The aim of the work To study the effects of various strains of SARS-CoV-2 on the clinical and epidemiological characteristics of pediatric patients; to determine the regularity between the severity of the disease and the circulating strain of SARS-CoV-2. Materials and methods A retrospective analysis of 945 case stories of COVID-19 disease in children who were hospitalized at the infectious diseases hospital (Kyiv, Ukraine) in the period from June 2020 to February 2022 (corresponding to a period of four waves of different SARS-CoV-2 strains). We investigated epidemiological and clinical features, as well as laboratory and instrumental parameters, comparing four waves of the disease. Results and Conclusions A regularity between the wave of COVID-19 and the severity of the disease was found. The third wave seemed to be the most severe, due to the increase in the frequency of complications, concomitant pathology, clinical symptoms and the level of mortality. The timing of this outbreak matched with the circulation of the SARS-CoV-2 delta-variant and correlated with an increase in hospitalization rates in Ukraine.
Кір являє собою висококонтагіозне захворювання вірусної природи. Навіть незважаючи на наявність безпечної й ефективної вакцини, ця хвороба залишається однією з головних причин смерті серед дітей у всьому світі. У 2017-2018 роках у різних країнах світу та в нашій країні зокрема спостерігається зростання кількості хворих на кір. В Україні на 41-й тиждень від початку 2018 року на кір захворіли 33 165 осіб, серед яких 13 184 дорослі та 19 981 дитина (https://phc.org.ua). Спалах кору, що триває, обумовлений переважно генотипами вірусу B3, D8 та D9, у той же час захворюваність на початку 2000-х років асоціювалась здебільшого з генотипом вірусу кору D6 [1, 2]. Метою даного дослідження було вивчення клінічних особливостей кору в дітей під час спалаху 2017-2018 рр. Матеріали та методи Було проведено ретроспективне дослідження 140 історій хвороби дітей, хворих на кір, які були госпіталізовані до міської дитячої клінічної лікарні міста Києва (КМДКІЛ) впродовж епідемічного підйому у 2017-2018 роках. Статистичний аналіз. Для надання даних розраховувались середні значення (М) та стандартні відхилення (SD). Різниця між кількісними показниками визначалась за допомогою однофакторного або багатофакторного тесту ANOVA, при невідповідності нормальному
Coronavirus disease (COVID-19), which was first recorded in China in December 2019, quickly spread to other countries and in a short period of time, the local outbreak escalated into a pandemic. There are significantly more cases of COVID-19 morbidity and mortality in European countries than in East Asia, where the disease was first detected. Such population differences are unique, especially for SARS-CoV-2 and are due to both socio-behavioral differences and features of the gene pool of the population of different countries. For infectious diseases, such as COVID-19, an important point is the genetic characteristics of individuals, which can determine its resistance or susceptibility to infection. Therefore, studies of the factors of hereditary predisposition to SARS-CoV-2 infection, as well as severity and mortality are extremely relevant. After genotyping among the healthy population of Ukraine and collecting relevant data from some European countries, we determined the correlation between morbidity, mortality from COVID-19 and the prevalence of genotype II (ACE1, I/D polymorphism) in the populations of Ukraine and several European countries. There was a negative correlation between the carrier of genotype II and susceptibility to SARS-CoV-2 infection per one million population ( R = –0.53, p < 0.05), so individuals with genotype II can be considered more resistant to infection SARS-CoV-2. Further study of the role of allelic variants of the ACE1 gene in the development of severity and complications affected patients of COVID-19, are promising for identified of genetic markers for development of personalized therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.