Mayonnaise is a popular condiment containing 65–75% oil by weight. The aim of the study was to develop a low fat (75% fat‐replaced) mayonnaise using chemically modified octenyl‐succinic anhydride (OSA) corn and OSA‐sorghum starches. Secondly, the functional properties of native and modified corn and sorghum starches were also compared. The setback viscosity of OSA‐sorghum starch was found to be the least while the textural changes in OSA‐sorghum on cold storage were found to be negligible. Overall acceptability of low fat mayonnaise (LFM) was scored higher than full‐fat mayonnaise (FFM). But the textural attributes of LFM made from OSA‐sorghum were found to be quite similar to FFM.
Extracts, fractions and gastrointestinal-resistant protein hydrolysates (GRPH) from rice bran (RB) of four Sri Lankan traditional varieties were studied for growth inhibition (GI) and cytotoxicity against human lung cancer (NCI-H460), cervical cancer (HeLa) cell lines and effect on glutathione S-transferase (GST) in vitro. RB extracts showed significantly high (P < 0.05) GI (GI50 μg/mL: HeLa: 19.24 ± 3.47 to 112.58 ± 0.05; NCI-H460: 54.63 ± 4.89 to 170.31 ± 4.71) and cytotoxicity (LC50 μg/mL: HeLa: 240.12 ± 9.23 to 476.22 ± 0.05; NCI-H460: 255.36 ± 1.81 to 412.07 ± 17.73) compared with GRPH. Highest GI (GI50: 30.63 ± 9.19 to 44.40 ± 5.34 μg/mL) and cytotoxicity (LC50: 141.31 ± 14.47 to 169.51 ± 2.04 μg/mL) was evident in nonpolar fractions (dichloromethane: Goda Heeneti and Sudu Heeneti; hexane: Dik Wee and Sudu Heeneti). No cytotoxicity was evident to normal cells. All RB extracts had high GST inhibition. Properties observed indicate its usefulness in managing lung and cervical cancers.
PRACTICAL APPLICATIONSLung and cervical cancers are two of the most commonly diagnosed cancers in men and women, respectively, and leading causes of mortality. Although numerous potent chemotherapeutic drugs are available for management, most of these drugs are very expensive and are associated with numerous side effects. Further, anticancer drugs containing electrophilic centers can easily form a conjugate with glutathione, which is facilitated by glutathione S-transferase (GST) and excreted from the body resulting in lower efficacy. Therefore, GST inhibitors are used as adjuvants during cancer chemotherapy. The selected rice varieties in this study claimed to possess health-enhancing properties according to Sri Lankan ethnomedicine. The findings of this study clearly showed that bran extracts, fractions and gastrointestinal-resistant protein hydrolysates of selected rice varieties had growth inhibition and cytotoxicity against both lung and cervical cancers. Further, all of these selected varieties had high GST inhibition. Therefore, selected rice brans may be useful in the management of lung and cervical cancers.
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