Due to advances in the acquisition and analysis of medical imaging, it is currently possible to quantify the tumor phenotype. The emerging field of Radiomics addresses this issue by converting medical images into minable data by extracting a large number of quantitative imaging features. One of the main challenges of Radiomics is tumor segmentation. Where manual delineation is time consuming and prone to inter-observer variability, it has been shown that semi-automated approaches are fast and reduce inter-observer variability. In this study, a semiautomatic region growing volumetric segmentation algorithm, implemented in the free and publicly available 3D-Slicer platform, was investigated in terms of its robustness for quantitative imaging feature extraction. Fifty-six 3D-radiomic features, quantifying phenotypic differences based on tumor intensity, shape and texture, were extracted from the computed tomography images of twenty lung cancer patients. These radiomic features were derived from the 3D-tumor volumes defined by three independent observers twice using 3D-Slicer, and compared to manual slice-by-slice delineations of five independent physicians in terms of intra-class correlation coefficient (ICC) and feature range. Radiomic features extracted from 3D-Slicer segmentations had significantly higher reproducibility (ICC = 0.85±0.15, p = 0.0009) compared to the features extracted from the manual segmentations (ICC = 0.77±0.17). Furthermore, we found that features extracted from 3D-Slicer segmentations were more robust, as the range was significantly smaller across observers (p = 3.819e-07), and overlapping with the feature ranges extracted from manual contouring (boundary lower: p = 0.007, higher: p = 5.863e-06). Our results show that 3D-Slicer segmented tumor volumes provide a better alternative to the manual delineation for feature quantification, as they yield more reproducible imaging descriptors. Therefore, 3D-Slicer can be employed for quantitative image feature extraction and image data mining research in large patient cohorts.
A fuzzy neural network model based on the multilayer perceptron, using the backpropagation algorithm, and capable of fuzzy classification of patterns is described. The input vector consists of membership values to linguistic properties while the output vector is defined in terms of fuzzy class membership values. This allows efficient modeling of fuzzy uncertain patterns with appropriate weights being assigned to the backpropagated errors depending upon the membership values at the corresponding outputs. During training, the learning rate is gradually decreased in discrete steps until the network converges to a minimum error solution. The effectiveness of the algorithm is demonstrated on a speech recognition problem. The results are compared with those of the conventional MLP, the Bayes classifier, and other related models.
The present article is a novel attempt in providing an exhaustive survey of neuro-fuzzy rule generation algorithms. Rule generation from artificial neural networks is gaining in popularity in recent times due to its capability of providing some insight to the user about the symbolic knowledge embedded within the network. Fuzzy sets are an aid in providing this information in a more human comprehensible or natural form, and can handle uncertainties at various levels. The neuro-fuzzy approach, symbiotically combining the merits of connectionist and fuzzy approaches, constitutes a key component of soft computing at this stage. To date, there has been no detailed and integrated categorization of the various neuro-fuzzy models used for rule generation. We propose to bring these together under a unified soft computing framework. Moreover, we include both rule extraction and rule refinement in the broader perspective of rule generation. Rules learned and generated for fuzzy reasoning and fuzzy control are also considered from this wider viewpoint. Models are grouped on the basis of their level of neuro-fuzzy synthesis. Use of other soft computing tools like genetic algorithms and rough sets are emphasized. Rule generation from fuzzy knowledge-based networks, which initially encode some crude domain knowledge, are found to result in more refined rules. Finally, real-life application to medical diagnosis is provided.
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