The results of this study indicate that a mouse model can be used to induce mechanical instability in the ankle.

The results of this study indicate that an acute ankle sprain in mice can result in the development of CAI-like symptoms 12 months after injury.

Transecting the lateral ligaments of a mouse hind foot resulted in lifelong sensorimotor dysfunction. Declines starting at 42 weeks postinjury may have represented the onset of posttraumatic osteoarthritis.

During the first 12 months of the lifespan, physical activity seemed to protect the joint from degeneration; however; after that there was no protective benefit. This may be due to the fact that C57Bl/6J mice are genetically known to develop OA at 9 months of age. Physical activity may have no impact on this genetic predisposition. Further study in mice not genetically predisposed to develop OA is needed.