Human T‐cell leukemia virus type 1 (HTLV‐1) is an oncogenic retrovirus; whereas HTLV‐1 mainly persists in the infected host cell as a provirus, it also causes a malignancy called adult T‐cell leukemia/lymphoma (ATLL) in about 5% of infection. HTLV‐1 replication is in most cases silent in vivo and viral de novo infection rarely occurs; HTLV‐1 rather relies on clonal proliferation of infected T cells for viral propagation as it multiplies the number of the provirus copies. It is mechanistically elusive how leukemic clones emerge during the course of HTLV‐1 infection in vivo and eventually cause the onset of ATLL. This review summarizes our current understanding of HTLV‐1 persistence and oncogenesis, with the incorporation of recent cutting‐edge discoveries obtained by high‐throughput sequencing.
With the rapid development of artificial intelligence technology, many researchers have begun to focus on visual language navigation, which is one of the most important tasks in multi-modal machine learning. The focus of this multi-modal field is how to fuse multiple inputs, which is crucial for the integrated feedback of intrinsic information. However, the existing models are only implemented through simple data augmentation or expansion, and are obviously far from being able to tap the intrinsic relationship between modalities. In this paper, to overcome these challenges, a novel multi-modal matching feedback self-tuning model is proposed, which is a novel neural network called Vital Information Matching Feedback Self-tuning Network (VIM-Net). Our VIM-Net network is mainly composed of two matching feedback modules, a visual matching feedback module (V-mat) and a trajectory matching feedback module (T-mat). Specifically, V-mat matches the target information of visual recognition with the entity information extracted by the command; T-mat matches the serialized trajectory feature with the direction of movement of the command. Ablation experiments and comparative experiments are conducted on the proposed model using the Matterport3D simulator and the Room-to-Room (R2R) benchmark datasets, and the final navigation effect is shown in detail. The results prove that the model proposed in this paper is indeed effective on the task.
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