Purpose: To compare the efficacy of Kane formula with Sanders Retzlaff Kraff/Theoretical (SRK/T) and Barrett Universal II in predicting intraocular lens (IOL) power in Indian eyes. Methods: This retrospective study conducted in a tertiary care eye hospital. Data from patients having uneventful cataract surgery with Tecnis ZCB00 IOL implantation were obtained from Lenstar and electronic medical records. Eyes were divided into subgroups based on axial length (AL) as short (<22.0 mm), medium (22–24 mm), and long (>24 mm). The predicted refractive outcome for each patient was calculated after optimizing the lens constant. Prediction error was calculated by subtracting the predicted spherical equivalent from achieved spherical equivalent 1 week post-surgery. The mean absolute error (MAE) and median absolute error (MedAE) and percentage of eyes within 0.25, 0.5, 1, and 2 D were calculated for each formula. Friedman test, Cochrane Q test were used for statistical analysis. Results: Out of the 350 eyes included in the study, we found that without lens constant optimization, Barrett formula performed better than SRK/T and Kane ( P < 0.0001). Over the entire range of axial lengths, Kane formula performed slightly inferior compared to Barrett and SRK-T, both of which performed equally well ( P = 0.006). On subgroup analysis, Kane formula performed inferiorly for medium eyes as compared to the other two. No significant differences were noted between the formulae for short and long eyes Conclusion: Kane formula did not outperform Barrett Universal II and SRK/T in Indian eyes.

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Objective: Syphilis is a sexually transmitted infection caused by the spirochaete, Treponema pallidum subspecies Pallidum nichols. In this study, a comparative metabolic pathway analysis and molecular docking were performed to identify putative drug targets. Methods:The biochemical pathways of T. pallidum subs. P. nichols and Homo sapiens were compared using kyoto encyclopedia of genes and genomes pathway(KEGG). The amino acid sequence of the selected enzymes were retrieved and Blastp was performed. Out of 9 enzymes, enolase was modeled using ModWeb, and the structure was validated using RAMPAGE. The active sites were identified using Metapocket 2.0 and further docked using AutoDock 4.2. Results:The enzymes which were not similar to that of H. sapiens were filtered out as potential drug targets. A total of 9 enzymes were retrieved which were present only in T. pallidum subs. P. nichols. The structure obtained from Homology modeling was validated using RAMPAGE which showed 96% of the residues in the favorable regions and 3% of the residues in the allowed region. Since the result obtained from RAMPAGE showed structural reliability further active sites were predicted. The docking analysis results showed the interaction between enolase and doxycycline. The atom H42 displayed in green has interacted with OD1 (Asp 317) with a distance of 1.9 Å depicts the best interaction and the structures were visualized using PyMol.Conclusion: Through this study, doxycycline which has antibacterial effect and a derivative of tetracycline could be one of the potential ligands against enolase.