A new robust adaptive controller is developed for the control of the hepatitis B virus (HBV) infection inside the body. The non-linear HBV model has three state variables: uninfected cells, infected cells and free viruses. A control law is designed for the antiviral therapy such that the volume of infected cells and the volume of free viruses are decreased to their desired values which are zero. One control input represents the efficiency of drug therapy in inhibiting viral production and the other control input represents the efficiency of drug therapy in blocking new infection. The proposed controller ensures the stability and robust performance in the presence of parametric and non-parametric uncertainties (and/or bounded disturbances). The global stability and tracking convergence of the process are investigated by employing the Lyapunov theorem. The performance of the proposed controller is evaluated using simulations by considering different levels of uncertainties. Based on the obtained results, the proposed strategy can achieve its desired objectives with different cases of uncertainties.
Drill strings are subjected to complex coupled dynamics. Therefore, accurate dynamic modeling, which can represent the physical behavior of real drill strings, is of great importance for system analysis and control. The most widely used dynamic models for such systems are the lumped element models, which neglect the system distributed feature. In this paper, a dynamic model called neutral-type time delay model is modified to investigate the coupled axial–torsional vibrations in drill strings. This model is derived directly from the distributed parameter model by employing the d'Alembert method. Coupling of axial and torsional vibration modes occurs in the bit–rock interface. For the first time, the neutral-type time delay model is combined with a bit–rock interaction model that regards cutting process in addition to frictional contact. Moreover, mistakes made in some of the related previous studies are corrected. The resulting equations of motion are in terms of neutral-type delay differential equations with two constant delays, related to the oscillatory behavior of the system, and a state-dependent delay, induced by the bit–rock interaction. Illustrative simulation results are presented for a representative drill string, which demonstrates intense axial and torsional vibrations that may lead to system failure without a controller.
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