No abstract

Hyperoxia reduces small bowel injury, accelerates enterocyte turnover, and improves intestinal rehabilitation after IR.

Background: Serum oxidative stress (OS) level has an important role in the inflammatory process of heart failure. Hypothesis:The study was designed to analyze serum OS levels in chronic heart failure (HF) patients and to examine the relation between OS levels and other clinical and prognostic parameters of HF. Methods: We studied 82 consecutive chronic symptomatic HF patients with systolic LV dysfunction (ejection fraction < 45%). The serum OS level was determined using thermochemiluminescence assay. We compared the serum OS levels with patients' clinical and prognostic parameters. Results: Higher serum OS levels were associated with higher New York Heart Association class (P = .01), worse renal function (serum urea, creatinine, and creatinine clearance) (P<.001) and higher serum levels of hs-C-reactive protein and N-terminal pro brain natriuretic peptide (P = .001, P<.001, respectively). Conclusions: In chronic systolic HF patients, high serum OS levels correlate with advanced disease and known markers of poor prognosis. IntroductionHeart failure (HF) is a major cardiovascular health problem, associated with high mortality and morbidity. Several studies suggested that inflammation has an important role in HF progression. Serum oxidative stress (OS) level is a crucial element of the inflammatory process, owing to the accumulation of reactive oxygen/nitrogen species that might provoke and exacerbate the myocardial damage of the already failing heart. 1 Several medications claim to have at least some beneficial effects through the antioxidant potential. 2 -6 The thermochemiluminescence (TCL) oxidiziability assay (Lumitest Ltd., Haifa, Israel), measures the OS level via photon emission counting from excited carbonyls in biological macromolecules. 7 TCL measurements were previously compared to other well accepted methods, which measure serum oxidative stress level via oxidation of lipids or proteins. 8 As we demonstrated before, TCL measurements were highly correlated with thiobarbituric acid reactive substances-(TBA assay), as well as with protein carbonyl formation (r = 0.99, r = 0.98, P<.01, respectively). 7 In this study, we investigated serum OS levels in chronic HF patients and examined the relation between OS levels and other clinical and laboratory prognostic parameters.