The adsorption of textile dyes such as Direct Red 75 and Direct Red 80 onto calcined bone was studied for their removal from aqueous solutions. The adsorption of Direct Red 75 and Direct Red 80 occurred by studying the effects of adsorbent amount, dye concentration, contact time, pH media and temperature. The adsorption rate data were analyzed using the intraparticle diffusion model, pseudo first order and the pseudo second order kinetic models to determine adsorption rate constants. The isotherms of adsorption data were analyzed by various adsorption isotherm models such as Langmuir, Freundlich and Tempkin. All results found concluded that calcined bone could be effectively employed as an effective new low cost adsorbent for the removal of textile dyes from aqueous solutions.

No abstract

No abstract

The development of CDK and GSK3 inhibitors has been regarded as a potential therapeutic approach, and a substantial number of diverse structures have been reported to inhibit CDKs and GSK-3β in recent years. Only a few molecules have gone through or are currently undergoing clinical trials as CDK and GSK inhibitors. In this paper, we prepared valmerins, a new family containing the tetrahydropyrido[1,2-a]isoindone core. The fused heterocycle was prepared with a straightforward synthesis that was functionalized by a (het)arylurea. Twelve valmerins inhibited the CDK5 and GSK3 with an IC(50) < 100 nM. A semiquantitative kinase scoring was realized, and a cellular screening was done. At the end of our study, we investigated the in vivo potency of one valmerin. Mice exhibited good tolerance to our lead, which proved its efficacy and clearly blocked tumor growth. Valmerins appear also as good candidates for further development as anticancer agents.

No abstract