Summary:We studied the effect of the CD34 ؉ cell dose on transplant-related mortality (TRM) and survival in 39 patients randomized to receive lenograstim-mobilized PBSCT (n = 20) or BMT (n = 19) from HLA-identical siblings. Both marrow and blood were harvested, and one infused in a double-blind fashion. The median nucleated
Summary.A cross-over study of glycosylated and nonglycosylated G-CSF was performed in 20 healthy male volunteers to compare the effects of the different forms of G-CSF, the extent of inter-individual progenitor cell mobilization and to determine whether any differences observed were related to the serum concentrations of G-CSF attained. The peak WBC achieved during 6 d of G-CSF administration at a dose of 5 mg/kg/d was significantly higher with the glycosylated than the non-glycosylated product (P ¼ 0 . 02) as was the peak level of granulocyte-monocyte colony forming cells (GM-CFC) (P ¼ 0 . 03). The average GM-CFC count on days 5, 6 and 7 was 28% higher with the glycosylated product (P ¼ 0 . 003). Serum concentrations of G-CSF achieved were significantly higher with the nonglycosylated G-CSF, however, suggesting that the difference in bio-efficacy was not due to a difference in G-CSF stability. Marked inter-individual variation in progenitor mobilization was observed, but this was not related to serum G-CSF levels. The G-CSF concentrations on day 6 were approximately one third of those on day 1, with both forms of G-CSF.
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