Aims The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.

Purpose High mortality and a limited performance of valvular surgery are typical features of infective endocarditis (IE) in octogenarians, even though surgical treatment is a major determinant of a successful outcome in IE. Methods Data from the prospective multicentre ESC EORP EURO-ENDO registry were used to assess the prognostic role of valvular surgery depending on age. Results As compared to < 80 yo patients, ≥ 80 yo had lower rates of theoretical indication for valvular surgery (49.1% vs. 60.3%, p < 0.001), of surgery performed (37.0% vs. 75.5%, p < 0.001), and a higher in-hospital (25.9% vs. 15.8%, p < 0.001) and 1-year mortality (41.3% vs. 22.2%, p < 0.001). By multivariable analysis, age per se was not predictive of 1-year mortality, but lack of surgical procedures when indicated was strongly predictive ). By propensity analysis, 304 ≥ 80 yo were matched to 608 < 80 yo patients. Propensity analysis confirmed the lower rate of indication for valvular surgery (51.3% vs. 57.2%, p = 0.031) and of surgery performed (35.3% vs. 68.4%, p < 0.0001) in ≥ 80 yo. Overall mortality remained higher in ≥ 80 yo (in-hospital: HR 1.50[1.06-2.13], p = 0.0210; 1-yr: HR 1.58[1.21-2.05], p = 0.0006), but was not different from that of < 80 yo among those who had surgery (in-hospital: 19.7% vs. 20.0%, p = 0.4236; 1-year: 27.3% vs. 25.5%, p = 0.7176). Conclusion Although mortality rates are consistently higher in ≥ 80 yo patients than in < 80 yo patients in the general population, mortality of surgery in ≥ 80 yo is similar to < 80 yo after matching patients. These results confirm the importance of a better recognition of surgical indication and of an increased performance of surgery in ≥ 80 yo patients.

Background Following an acute coronary syndrome, ischemic myocardial dysfunction has several degrees of severity and different outcomes from a total or partial recovery to an irreversible injury. In this study led in non-ST elevation myocardial infarction (NSTEMI) patients without otherwise previous non-ischemic cardiomyopathy (NICM), we investigated the correlation between 2D global longitudinal strain (GLS) and angiographic prognostic factors. The ability of territorial longitudinal strain (TLS), defined as the sum of segmental strain in a coronary territory,to identify culprit artery occlusion was also assessed. Methods 82 consecutive NSTEMI patients were prospectively screened for inclusion; 70 of them without NICM were enrolled. Severe coronary artery disease (CAD) was defined as three-vessel disease or a left main disease. Group 1 and 2 were defined by the presence or not of severe CAD. Statics ‘analyses was performed with IBM SPSS Statistics (version 22). Results mean age of patients was 60, 2 ±10 years. 37 patients had diabetes mellitus (53%), 31 had hypertension (44%), 21 had dyslipidemia (30%) and 5 had renal insufficiency (7%). Severe CAD was present in 24 patients (34%). The first ultrasound exam showed that mean EF was 49 ± 11, mean WMSI was 1.43 ± 0.4 and mean GLS was -14.9 ± 4. GLS was higher in group 1 (-12.82 ± 0.95 vs -16.04 ± 0.42; p &lt; 0.001); LVEF and WMSI in group 1 and 2 were (43.3 ± 13.5% Vs 52.7 ± 7.9%; p &lt; 0.001) and (1.64 ± 0.1 Vs 1.32 ± 0.04; p &lt; 0.001) respectively. Correlations were found between LVEF and GLS (p = 0.004), and between WMSI and GLS (p = 0.002) . TLS was able to discriminate between coronary stenosis of LAD, LCX or RCA and to predict the occlusion of the culprit vessel: 7 patients had acute coronary occlusion (10%). TLS was -7.4 ± 5.1 in patients with coronary occlusion and -14.1 ± 6 in the absence of coronary occlusion (p &lt; 0.001). A cut off of -9.5 was able to detect this occlusion with a specificity of 82% and a sensitivity of 85%. The second ultrasound exam, performed after a median of 10 ± 3.1 months, showed a statistically significant improvement of EF (53 ± 10, p =0.02), WMSI (1.35 ± 0.39, p= 0.01) as well as GLS (-17.1 ± 4.2, p =0.004). Patients who received only medical treatment (n = 11) had the lowest variation of EF (47% to 48 %; p = 0.7), WMSI (1.62 to 1.59; p = 0.69) and GLS (14.2 to 15.2; p = 0.2) with no statistical correlation between the two exams. While patients who had PCI or bypass revascularization, had the best outcome with improvement of EF (49% to 53%; p = 0.002), WMSI (1.4 to 1.32;p = 0.01) and GLS (15 to 17.4;p = 0.004). Conclusion GLS is a strong diagnostic and prognostic ultra sound parameter for NSTEMI patients correlated to CAD severity. Strain is a reliable parameter during follow up.TLS can be used to localize the culprit coronary artery and especially to predict its occlusion during the acute phase of NSTEMI which can lead to a different therapeutic strategy.

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