Breast cancer remains the most common cancer in women. A diagnosis of cancer during pregnancy is uncommon. In recent decades, obstetricians are seeing an increasing number of women who become pregnant or desire to become pregnant after breast cancer treatment because of a delay in childbearing for a variety of reasons, including cultural, educational, and professional. Consequently, breast cancer in young women often occurs before the completion of reproductive plans.A discussion among the patient, the oncologist, and the obstetrician on the relative benefits of early delivery followed by treatment versus commencement of therapy while continuing the pregnancy is of utmost importance in order to reach a consensual decision. The best available evidence suggests that pregnancy after breast cancer increases the risk of recurrence. The birth outcome in women with a history of breast cancer is no different from that in the normal female population; however, increased risks of delivery complications have been reported in the literature.As concurrent pregnancy and breast cancer are uncommon, there are no data from large randomized trials; hence, recommendations are mainly based on retrospective studies.
Background. Rosai-Dorfman Disease (RDD) is rare benign hematologic disorder of histiocytes, which usually manifests as painless lymphadenopathy, fever, leukocytosis and hypergammaglobulinemia. Extranodal RDD has been reported in 43% of cases, with skin as commonly involved site followed by head and neck region. However, soft tissue cheek mass is rare presentation of extra-nodal RDD. Case Presentation. A 26-year-old Saudi man presented with a six-month history of right cheek swelling and left upper eyelid swelling. Physical examination revealed right cheek mass of size 3 × 3 cm and left upper eyelid mass of size 1 × 2 cm and no palpable cervical lymphadenopathy. Incisional biopsy of cheek mass showed positivity for S100 and negativity for CD1a, consistent with extra-nodal RDD. Patient did not respond to systemic steroids and was given radiation therapy to left orbit with minimal response. Then, he was started on chemotherapy Rituximab, cyclophosphamide, vincristine, and prednisolone (RCVP) 8 cycles followed by reirradiation 10 Gy in 10 fractions with 6 MeV electron with complete response. After 12 months of followup, patient had recurrence in right cheek and was started on radiotherapy to the cheek mass. Conclusion. Extra-nodal RDD with involvement of cheek is a rare presentation. Incorporation of S100 and CD1a is helpful in diagnoses of RDD and differentiating it from other benign histiocytosis. Treatment consists of surgery, steroids, chemotherapy, and radiation therapy.
A 30-year-old male presented at our hospital with pain in the front of the right thigh, for which he had undergone a series of investigations by the neurologists. MRI showed a large lump within the right psoas muscle, in close relationship to L2 nerve root, and at a level that was 2cm below the lower pole of the right kidney. There were areas of degeneration in the central aspect of the tumour, which showed medial intracanalicular extension along the root of L2. The radiological appearance was highly suggestive of schwannoma with an extension to L2 nerve root. The anatomical position of the schwannoma was intra-psoas. After detailed discussion with the patient about a possible need of open surgery and probability of injury to the lumbar sacral plexus in close relation to the tumour, we proceeded with laparoscopic surgery technique Patient was placed in supine position with legs split, surgeon stood between the legs of the patient and the camera person was to the left side of the surgeon, first assistant to the right side. We decided to proceed with an intraperitoneal approach to the retroperitoneum, with medial colonic reflection. Initially it was accessed through the suprapubic port with the left hand working port in the right iliac fossa and the right hand working port in the left iliac fossa, augmented by a 10mm port through the umbilicus that was used initially for right hand working, and was later used for the telescope.Initially the terminal ileum, the appendix, and the caecum were mobilized and lifted off the retroperitoneum. Then the port in the left iliac fossa was used to grasp these structures and reflect them medially and right hand working port through the umbilicus was used to continue the right paracolic dissection upto to the hepatic flexure and then to turn medially in order to expose the complete retroperitoneum [Table/ Fig-2].The anterior surface of the Gerota's fascia was completely exposed upto the level of the adrenal gland. The right ureter was identified and traced throughout its course [Table/ Fig-3].Progressive medial mobilization of the right colon allowed us to identify and preserve the duodenum and the complete Inferia Vena Cava (IVC). At this stage the psoas and the ilio-psoas tendon were both seen clearly. By correlation with the MRI we were able to then do a psoas split (a longitudinal 5cm muscle split of the psoas major lateral to genito-femoral nerve which was identified and preserved).Wide longitudinal splitting of psoas major helps to expose the anterior surface of the capsule of the tumour [Table /Fig-4]. By careful dissection just outside the capsule, and by coagulating and dividing all the feeding vessels to and from the tumour, a plane was developed all around. We found the suture traction technique to be useful, and would like to recommend it too. Sutures were taken on the capsule of the tumour with 2-0 polypropolene which were held with the needle holder for retraction to expose further the surface and edges of the tumour [Table /Fig-5].The medial dissection was kept to...
Background. Uterine leiomyosarcoma is a rare and aggressive gynecologic malignancy with an overall poor prognosis. Lungs, bones, and brain are common sites of metastases of uterine leiomyosarcoma. Metastases of uterine leiomyosarcoma to the small bowel are extremely rare, and only four case reports have been published to date. Case presentation. A 55-year-old Saudi woman diagnosed with a case of uterine leiomyosarcoma treated with total abdominal hysterectomy (TAH) and bilateral salpingooophorectomy (BSO) presented in emergency room after sixteen months with acute abdomen. Subsequent work-up showed a jejunal mass for which resection and end-to-end anastomosis were performed. Biopsy confirmed the diagnosis of small bowel metastasis from uterine leiomyosarcoma. Further staging work-up showed wide spread metastasis in lungs and brain. After palliative cranial irradiation, systemic chemotherapy based on single agent doxorubicin was started. Conclusion. Metastatic leiomyosarcoma of small bowel from uterine leiomyosarcoma is a rare entity and is sign of advanced disease. It should be differentiated from primary leiomyosarcoma of small bowel as both are treated with different systemic chemotherapeutic agents.
HighlightsInguinal lymph nodes metastasis are rare in endometrial carcinoma.Proper preoperative assessment is important.CT-PET imaging is important tool in obese patients.Treatment is surgery and adjuvant chemo-radiotherapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.