PurposeThe purpose of this study is to explore how digital transformation helps enterprises achieve high-quality development, including the mediating mechanism of information transparency, innovation capacity and financial stability, the moderating role of financing constraints and government subsidies, and the heterogeneous effects of property rights, size and growth.Design/methodology/approachThis study conducts two-way fixed-effect model using 780 samples of China's Shanghai-Shenzhen A-share listed companies from 2012 to 2019.FindingsThe results show that digital transformation can effectively improve the total factor productivity (TFP) of enterprises through the triple channels of information transparency, innovation capability and financial stability. Meanwhile, financing constraints significantly inhibited the contribution of digital transformation to TFP, while government subsidies significantly increased the contribution of digital transformation to TFP. In addition, state-owned enterprises (SOEs), large enterprises and high-growth enterprises are more able to achieve high-quality development by increasing their digital transformation.Practical implicationsIn the process of implementing digital transformation, companies should actively improve information transparency, financial stability and innovation capabilities, and choose differentiated paths based on intrinsic characteristics such as property rights, scale and growth. At the same time, the government should actively improve not only the digital institutional environment but also the financial policy and credit system.Originality/valueThis study enriches the theoretical research framework of digital transformation and high-quality development by identifying the channel mechanisms and boundary conditions through which digital transformation affects high-quality development and expands the consequences of digital transformation and the antecedents of high-quality development.
In this study, it is shown for the first time that a reduced graphene oxide (rGO) carrier has a 20‐fold higher catalysis rate than graphene oxide in Ag+ reduction. Based on this, a tumor microenvironment‐enabled in situ silver‐based electrochemical oncolytic bioreactor (SEOB) which switched Ag+ prodrugs into in situ therapeutic silver nanoparticles with and above 95% transition rate is constructed to inhibit the growths of various tumors. In this SEOB‐enabled intratumoral nanosynthetic medicine, intratumoral H2O2 and rGO act as the reductant and the catalyst, respectively. Chelation of aptamers to the SEOB‐unlocked prodrugs increases the production of silver nanoparticles in tumor cells, especially in the presence of Vitamin C, which is broken down in tumor cells to supply massive amounts of H2O2. Consequently, apoptosis and pyroptosis are induced to cooperatively contribute to the considerably‐elevated anti‐tumor effects on subcutaneous HepG2 and A549 tumors and orthotopic implanted HepG2 tumors in livers of nude mice. The specific aptamer targeting and intratumoral silver nanoparticle production guarantee excellent biosafety since it fails to elicit tissue damages in monkeys, which greatly increases the clinical translation potential of the SEOB system.
In this letter, we demonstrate the fabrication of a conformal CuO/Si microholes array heterojunction through the DC reactive magnetron sputtering from a high-purity Cu target. By using the monolayer graphene as the top electrode, the device served well as a self-powered vis-NIR photodetector, showing a high responsivity of 301.5 mA W −1 , specific detectivity of 7.96 × 10 12 Jones and a fast response speed (rise time 9.9µ s and fall time 10µs) upon 530 nm illumination. Compared to its planar counterpart, the responsivity was remarkably enhanced over the broadband region. The underlying reason should be ascribed to the improved light trapping in the microholes via the longitudinal Fabry-Perot (F-P) cavity resonance, according to theoretical simulation by finite-difference timedomain (FDTD) solution. Such an effect gave rise to an enhanced light-matter interaction, leading to the improved photoresponse. This work also opens up an effective way for the on-chip high performance photodetection due to the well compatibility with the current complementary metal-oxidesemiconductor (CMOS) technology. Index Terms-Fabry-Perot cavity resonance, light trapping, microholes array, broadband photodetection. I. INTRODUCTIONB ULK crystalline Si is a leading material for commercial visible light photodetectors due to its suitable bandgap (∼1.12 eV), high carrier mobility, long-term stability, abundant material resources and the mature Si-based semiconductor manufacturing techniques [1]. However, the optical reflection loss of crystalline Si in visible region is up to 40% due to its high reflective index, which seriously limits the efficiency Manuscript
Bioreactors In article number 2109973, Liping Zhong, Kun Zhang, Yongxiang Zhao, and co‐workers describe how a tumor‐microenvironment‐enabled in situ silver‐based electrochemical oncolytic bioreactor (SEOB) unlocks antitumor Ag+ prodrugs for highly efficient subcutaneous and orthotopic tumor recession via activating production of reactive oxygen species (ROS). Reduced graphene oxide (rGO), featuring 20‐fold larger catalysis rate than GO, allows intratumoral H2O2 as reductants to reduce Ag+ into silver nanoparticles especially after uniting with vitamin‐C‐mediated H2O2 production.
Skin interstitial fluid (ISF) has emerged as a fungible biofluid sample for blood serum and plasma for disease diagnosis and therapy. The sampling of skin ISF is highly desirable considering its easy accessibility, no damage to blood vessels, and reduced risk of infection. Particularly, skin ISF can be sampled using microneedle (MN)-based platforms in the skin tissues, which exhibit multiple advantages including minimal invasion of the skin tissues, less pain, ease of carrying, capacity for continuous monitoring, etc. In this review, we focus on the current development of microneedle-integrated transdermal sensors for collecting ISF and detecting specific disease biomarkers. Firstly, we discussed and classified microneedles according to their structural design, including solid MNs, hollow MNs, porous MNs, and coated MNs. Subsequently, we elaborate on the construction of MN-integrated sensors for metabolic analysis with highlights on the electrochemical, fluorescent, chemical chromogenic, immunodiagnostic, and molecular diagnostic MN-integrated sensors. Finally, we discuss the current challenges and future direction for developing MN-based platforms for ISF extraction and sensing applications.
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