Background:
In recent years, nanotechnology is gaining more attention of analytical and
biomedical researchers. Nanotechnology derived nanotools deal with the nanoscale length size (i.e.,
10-9 m). The particles having size below 100 nm displayed improved properties for attaining increased
efficacy, better patient compliance, improved biodistribution and site-specific drug delivery.
Method:
Google, PubMed, Web of Science portals have been searched for potentially relevant literature
to get latest developments and updated information related to different aspects of nanotechnology
derived nanocarriers including biomedical applications.
Results:
Available literature demonstrated that nanotechnology-based nanocarriers like liposomes,
dendrimers, polymeric micelles, carbon dots, quantum dots, carbon nanotubes, magnetic nanoparticles,
silica nanoparticles, silver nanoparticles and gold nanoparticles have enormous potential applications
in the pharmaceutical field. The current review focuses on the drug delivery, bioimaging,
tissue engineering and therapeutic applications of different nanotools. Besides these, scope and opportunities,
as well as the global market scenario of nanotechnology derived nanotools, have also
been discussed.
The practice of nanotechnology in the arena of medicine will transform the strategies of
detection and treatment of a wide range of diseases in the upcoming years.
Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide- and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW.
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