No abstract

A clean, cost-effective and very practical approach has been disclosed for the one-pot, cyclo condensation of aromatic aldehydes with different thiosemicarbazides in aqueous ethanol leading to pharmaceutically diverse 5-aryl-1,2,4-triazolidine-3thiones in good yields under neutral reaction conditions. Simple operational procedure, high product yield, rapid and use of green solvent system make this protocol economical as well as environmentally benevolent.

No abstract

A straightforward and greener PEG-assisted protocol has been disclosed for the synthesis of 5-aryl-1,2,4-triazolidine-3-thiones via the reaction of aromatic aldehydes and thiosemicarbazides using very convenient neutral reaction conditions.