Background: This study aimed to explore the value of extended motor nerve conduction studies in patients with ulnar nerve entrapment at the elbow (UNE) in order to find the most sensitive and least time-consuming method. We wanted to evaluate the utility of examining both the sensory branch from the fifth finger and the dorsal branch of the ulnar nerve. Further we intended to study the clinical symptoms and findings, and a possible correlation between the neurophysiological findings and pain.
A definitely abnormal EEG suggests epilepsy or symptomatic seizures unrelated to alcohol. The predictive value of a normal EEG is limited, but the typical post-ictal finding in ARS is nevertheless a normal low-amplitude EEG record.
Summary:Purpose: Patients with autosomal dominant lateral temporal lobe epilepsy (ADTLE) may have seizures precipitated by sound or speech. We have examined a patient with speechinduced seizures caused by an LGI1 mutation (C46R).Methods: A clinical study and a video-EEG recording using interrogative speech as the activation procedure was performed in a 23-year-old man.Results: He had experienced short episodes of sensory aphasia in situations in which he was suddenly verbally addressed. Voices became distorted, and he could not comprehend despite hearing words. The day after a late party, his girlfriend unexpectedly spoke to him. Her speech became unintelligible to him. He did not reply and had a generalized tonic-clonic (GTC) seizure. During an EEG, he was suddenly asked for the names of his siblings. He answered, but lost understanding of the further conversation and described how syllables floated together with an echoing character. With a versive movement to the right, another GTC occurred. In the EEG, rhythmic 6-Hz activity built up in the frontotemporal areas starting on the left side with bilateral and posterior spreading. Postictal slowing was symmetrical, and no aphasia was noted on awakening.Conclusions: To our knowledge, this is the first video-EEG recorded seizure in LGI1-caused ADTLE. This peculiar seizure semiology and precipitating effect of speech may serve as a marker for identifying further individuals with this particular phenotype and genotype and may indicate that the LGI1 gene may have a physiologic function connected to the human capacity for speech and language.
The idiopathic generalized epilepsies (IGE) occur with a high aggregation within families. Juvenile myoclonic epilepsy (JME) is recognized as a commonly occurring form of idiopathic generalized epilepsy. A possible association between JME and HLA antigens was investigated by serological typing of human leukocyte antigens (HLA) class I antigens and by DNA oligotyping of class II antigens. Twenty-four patients and 129 controls, all Caucasians of Scandinavian descent, were tested. Uncorrected there was a significant positive association (Relative risk (RR) = 8.07) to B17 and a significant negative association (RR = 0.13) to B8 as well as DRB1*3. The negative association to DQ alleles DQA1*0501 and DQB1*0201, which are in strong linkage disequilibrium with the alleles B8 and DRB1*3, was weaker and not significant, thus giving no clue as to a primary HLA-DQ association of JME.
OVERSIKTSARTIKKELKUNNSKAPSGRUNNLAG Artikkelen bygger på en gjennomgang av aktuelle laerebøker og artikler fra eget litteraturarkiv, selektive søk i PubMed samt egne kliniske erfaringer.RESULTATER Intraoperativ nevrofysiologisk monitorering omfatter både kontinuerlig overvåking av nervevev og lokalisering av vitale nevrologiske strukturer. Slik monitorering kan redusere risiko for skader på nerver og nervebaner og er mest brukt ved skolioseoperasjoner og nevrokirurgiske operasjoner. Behovet for nevrofysiologisk monitorering påvirker valg av anestesimetode, ettersom noen anestetika påvirker monitoreringen.FORTOLKNING Intraoperativ nevrofysiologisk monitorering er avhengig av godt samarbeid mellom nevrofysiologer, kirurger, anestesiologer og andre involverte spesialiteter.
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