No abstract

α-Hydroxyphosphonates 2a-g derived from 2-chloroquinolin-3-carbaldehyde 1a-g by modified Abramov reaction using chloro(trimethyl)silane (TMSCl) and subsequent α-hydroxyphosphonate produced were acetylated using acetic anhydride in the presence of 1,8-Diazabicyclo-undec-7-ene (DBU) to afford the α-acetyloxyphosphonate 3a-g in high yields. The synthesized α-hydroxyphosphonate and α-acetyloxyphosphonate compounds were screened for antibacterial activities. The compound no. 2d, 2e and 3e, 3f has shown comparative activity against their standard Streptomycin.

Indole derivatives R 0140Alum Catalyzed Simple and Efficient Synthesis of Bis(indolyl)methanes by Ultrasound Approach. -The reaction of aryl or heteroaryl aldehydes and ketones (I) with indole (II) is carried out under optimized conditions and yields the bis(indolyl)methanes (III) in short reaction times and excellent yields. Alum works as an efficient and safe catalyst. Further advantages offered by this method are the simple procedure, the solvent-free reaction conditions, and the easiness of product isolation. -(SONAR, S. S.; SADAPHAL, S. A.; KATEGAONKAR, A. H.; POKALWAR, R. U.; SHINGATE, B. B.; SHINGARE*, M. S.; Bull. Korean Chem. Soc. 30 (2009) 4, 825-828; Dep. Chem., Marathwada Univ., Aurangabad 431 004, India; Eng.) -H. Hoennerscheid 36-111

An efficient and novel one-pot synthesis of new 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature grinding is presented. The six-membered N,O-heterocyclic skeleton was constructed via zirconyl(IV) chloride promoted Mannich type reaction. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. The results of preliminary bioassay indicate that some of title compounds possess significant antibacterial and antifungal activity.

No abstract