Recent results of the searches for Supersymmetry in final states with one or two leptons at CMS are presented. Many Supersymmetry scenarios, including the Constrained Minimal Supersymmetric extension of the Standard Model (CMSSM), predict a substantial amount of events containing leptons, while the largest fraction of Standard Model background events -which are QCD interactions -gets strongly reduced by requiring isolated leptons. The analyzed data was taken in 2011 and corresponds to an integrated luminosity of approximately L = 1 fb −1 . The center-of-mass energy of the pp collisions was √ s = 7 TeV.

A detailed analysis is presented of the diffractive deep-inelastic scattering process ep → eXY , where Y is a proton or a low mass proton excitation carrying a fraction 1−x I P > 0.95 of the incident proton longitudinal momentum and the squared four-momentum transfer at the proton vertex satisfies |t| < 1 GeV 2 . Using data taken by the H1 experiment, the cross section is measured for photon virtualities in the range 3.5 ≤ Q 2 ≤ 1600 GeV 2 , triple differentially in x I P , Q 2 and β = x/x I P , where x is the Bjorken scaling variable. At low x I P , the data are consistent with a factorisable x I P dependence, which can be described by the exchange of an effective pomeron trajectory with intercept α IP (0) = 1.118 ± 0.008 (exp.) +0.029 −0.010 (model). Diffractive parton distribution functions and their uncertainties are determined from a next-to-leading order DGLAP QCD analysis of the Q 2 and β dependences of the cross section. The resulting gluon distribution carries an integrated fraction of around 70% of the exchanged momentum in the Q 2 range studied. Total and differential cross sections are also measured for the diffractive charged current process e + p →ν e XY and are found to be well described by predictions based on the diffractive parton distributions. The ratio of the diffractive to the inclusive neutral current ep cross sections is studied. Over most of the kinematic range, this ratio shows no significant dependence on Q 2 at fixed x I P and x or on x at fixed Q 2 and β.

A measurement of charm and beauty dijet photoproduction cross sections at the ep collider HERA is presented. Events are selected with two or more jets of transverse momentum p jet 1(2) t > 11(8) GeV in the central range of pseudo-rapidity −0.9 < η jet 1(2) < 1.3. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured by the H1 central vertex detector. Differential dijet cross sections for charm and beauty, and their relative contributions to the flavour inclusive dijet photoproduction cross section, are measured as a function of the transverse momentum of the leading jet, the average pseudo-rapidity of the two jets and the observable x obs γ . Taking into account the theoretical uncertainties, the charm cross sections are consistent with a QCD calculation in next-to-leading order, while the predicted cross sections for beauty production are somewhat lower than the measurement.

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The cross section for the diffractive deep-inelastic scattering process ep → eXp is measured, with the leading final state proton detected in the H1 Forward Proton Spectrometer. The data analysed cover the range x IP < 0.1 in fractional proton longitudinal momentum loss, 0.08 < |t| < 0.5 GeV −2 in squared four-momentum transfer at the proton vertex, 2 < Q 2 < 50 GeV 2 in photon virtuality and 0.004 < β = x/x IP < 1, where x is the Bjorken scaling variable. For x IP < ∼ 10 −2 , the differential cross section has a dependence of approximately dσ/dt ∝ e 6t , independently of x IP , β and Q 2 within uncertainties. The cross section is also measured triple differentially in x IP , β and Q 2 . The x IP dependence is interpreted in terms of an effective pomeron trajectory with intercept α IP (0) = 1.114±0.018 (stat.)±0.012 (syst.) +0.040 −0.020 (model) and a sub-leading exchange. The data are in good agreement with an H1 measurement for which the event selection is based on a large gap in the rapidity distribution of the final state hadrons, after accounting for proton dissociation contributions in the latter. Within uncertainties, the dependence of the cross section on x and Q 2 can thus be factorised from the dependences on all studied variables which characterise the proton vertex, for both the pomeron and the sub-leading exchange.

Measurements are presented of differential dijet cross sections in diffractive photoproduction (É ¾ ¼ ¼½ GeV ¾ ) and deep-inelastic scattering processes (DIS,The event topology is given by Ô , in which the system , containing at least two jets, is separated from a leading low-mass proton remnant system by a large rapidity gap. The dijet cross sections are compared with NLO QCD predictions based on diffractive parton densities previously obtained from a QCD analysis of inclusive diffractive DIS cross sections by H1. In DIS, the dijet data are well described, supporting the validity of QCD factorisation. The diffractive DIS dijet data are more sensitive to the diffractive gluon density at high fractional parton momentum than the measurements of inclusive diffractive DIS. In photoproduction, the predicted dijet cross section has to be multiplied by a factor of approximately ¼ for both direct and resolved photon interactions to describe the measurements. The ratio of measured dijet cross section to NLO prediction in photoproduction is a factor ¼ ¦ ¼ ½ smaller than the same ratio in DIS. This suppression is the first clear observation of QCD hard scattering factorisation breaking at HERA. The measurements are also compared to the two soft colour neutralisation models SCI and GAL. The SCI model describes diffractive dijet production in DIS but not in photoproduction. The GAL model fails in both kinematic regions.

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Stroke is a major cause of serious disability due to the brain’s limited capacity to regenerate damaged tissue and neuronal circuits. After ischemic injury, a multiphasic degenerative and inflammatory response is coupled with severely restricted vascular and neuronal repair, resulting in permanent functional deficits. Although clinical evidence indicates that revascularization of the ischemic brain regions is crucial for functional recovery, no therapeutics that promote angiogenesis after cerebral stroke are currently available. Besides vascular growth factors, guidance molecules have been identified to regulate aspects of angiogenesis in the central nervous system (CNS) and may provide targets for therapeutic angiogenesis. In this study, we demonstrate that genetic deletion of the neurite outgrowth inhibitor Nogo-A or one of its corresponding receptors, S1PR2, improves vascular sprouting and repair and reduces neurological deficits after cerebral ischemia in mice. These findings were reproduced in a therapeutic approach using intrathecal anti–Nogo-A antibodies; such a therapy is currently in clinical testing for spinal cord injury. These results provide a basis for a therapeutic blockage of inhibitory guidance molecules to improve vascular and neural repair after ischemic CNS injuries.