We present ALMA Band 9 observations of the [C II]158µ m emission for a sample of 10 main-sequence galaxies at redshift z∼2, with typical stellar masses (log M /M ∼10.0-10.9) and star formation rates (∼35-115 M yr −1 ). Given the strong and well understood evolution of the interstellar medium from the present to z = 2, we investigate the behaviour of the [C II] emission and empirically identify its primary driver. We detect [C II] from six galaxies (four secure, two tentative) and estimate ensemble averages including non detections. The [C II]-to-infrared luminosity ratio (L [C II] /L IR ) of our sample is similar to that of local main-sequence galaxies (∼ 2 × 10 −3 ), and ∼ 10 times higher than that of starbursts. The [C II] emission has an average spatial extent of 4 -7 kpc, consistent with the optical size. Complementing our sample with literature data, we find that the [C II] luminosity correlates with galaxies' molecular gas mass, with a mean absolute deviation of 0.2 dex and without evident systematics: the [C II]-to-H 2 conversion factor (α [C II] ∼ 30 M /L ) is largely independent of galaxies' depletion time, metallicity, and redshift. [C II] seems therefore a convenient tracer to estimate galaxies' molecular gas content regardless of their starburst or main-sequence nature, and extending to metal-poor galaxies at low-and high-redshifts. The dearth of [C II] emission reported for z > 6-7 galaxies might suggest either a high star formation efficiency or a small fraction of UV light from star formation reprocessed by dust.