Hepatocyte transplantation has been investigated in patients with liver-based metabolic disorders and acute liver failure. We report the first use of hepatocyte transplantation in two brothers with severe inherited coagulation factor VII deficiency. Patient 1 received a total of 1.09x10(9) cryopreserved hepatocytes, and patient received 2.18x10(9) fresh and cryopreserved hepatocytes through a Hickman line inserted in the inferior mesenteric vein. Infusion of isolated human hepatocytes improved the coagulation defect and markedly decreased the requirement for exogenous recombinant factor VII (rFVIIa) to approximately 20% of that before cell transplantation. In both patients, episodes of line sepsis were associated with an increase in rFVIIa requirement. Six months posthepatocyte transplantation, higher rFVIIa doses were required, suggesting loss of transplanted hepatocyte function. Because of increasing problems with venous access and long-term uncertainty of the efficacy of hepatocyte transplantation, orthotopic liver transplantation was performed successfully in both cases.

A consistent number of patients with SVT and/or cirrhosis are currently treated with DOACs, which seem to be effective and safe. These data provide a basis for performing randomized clinical trials of DOACs vs. low molecular weight heparin or vitamin K antagonists.

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The link between Diabetes mellitus & Tuberculosis has been recognizing for centuries. Recently Tuberculosis has re-emerged as a major health concern. There is growing evidence that Diabetes mellitus with Tuberculosis may affect disease presentation and treatment. The Tuberculosis also influences glucose intolerance and influences the glycaemic control in the people with Diabetes mellitus. Approximately 2 Million persons worldwide died of Tuberculosis and 9 Million become infected each year. (CDC, 2007) 1. With the convergence of tuberculosis and diabetes Mellitus epidemic, co-affliction with the two diseases is on the rise. The observational study was conducted with 100 patients. The patients with Pulmonary Tuberculosis sputum positive/negative with radiological lesions was admitted in medicine wards of our hospital between years 2009-2011. The aim of our study is to find out the prevalence of GTT in patients of Pulmonary Tuberculosis Age, sex distribution of impaired Glucose Tolerance Test (GTT) in Patients with pulmonary tuberculosis and study the correlation between impaired GTT with Sputum positivity and also radiological extent of disease. The patients were subjected to oral GTT and results were evaluated according to the WHO criteria and the statistical analysis was done to determine the P value and significance on the basis Chi-square test. The results found in the studied patient were that prevalence of abnormal GTT in Pulmonary Tuberculosis patients was found to be 22% (P=0.07). Abnormal GTT was more common in males as compared to females and this was found to be significant (P=0.692). Sputum positive Pulmonary Tuberculosis is strongly associated in patients with abnormal GTT (P=0.03), and bilateral lung involvement was more common among Pulmonary Tuberculosis patients with abnormal GTT.

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