A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its characterization by X-ray, N2 absorption-desorption isotherm, and thermogravimetry analysis have been described. Drug loading was performed by a soaking procedure. Drug-loaded matrices were characterized for entrapped drug amount, water absorption ability, and thermogravimetric behavior. Drug release studies also were performed at pH 1.1 and 6.8 mimicking gastrointestinal fluids. Experimental results showed that this type of matrix is able to trap the bioactive agents by a soaking procedure and, then, to release them in conditions mimicking the biological fluids. Also, the high affinity of these matrices for water makes them potentially biocompatible. Release data suggest that the matrix impregnated with diflunisal offers good potential as a system for the modified drug release.
Mesostructured films are an ideal material for incorporation of fluorescent dyes; controlling the doping process is, however, a critical step because the dyes will be constrained in a complex chemical environment. We have incorporated rhodamine 6G, a well-known fluorescent dye, in silica mesostructured 2d-hexagonal films at different concentrations. We have used dense silica films as reference material to compare the effect of incorporation of rhodamine 6G in mesostructured and dense materials. We have also prepared mesostructured films at different surfactant concentrations to compare the surfactant effect on dye aggregation state. The dye-doped films have been characterized by UV-vis absorption spectroscopy and emission and excitation fluorescence spectroscopy. At high dye concentrations, nonfluorescent sandwich H-type dimers are formed, but in mesostructured films the amount of this type of aggregates is reduced and the formation of fluorescent J-type dimers is favored. The presence of the surfactant within the mesopores gives rise to fluorescent dimers (J-type) at the expense of the nonfluorescent sandwich H-type.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.