A Cs 2 CO 3 -mediated [2 + 1] cycloaddition of benzofuran-derived azadienes (BDAs) with bromomalonate by using a dearomatization strategy has been developed. Through this process, BDAs serve as a potential 2-atom synthon in the construction of a range of functionalized spirocyclopropane derivatives, such as spirobenzofuran-2-cyclopropanes and spiroindane-2-cyclopropanes.
An unusual [2 + 3]
cycloaddition of isatin azomethine imines (AIs)
and in situ generated azaoxyallyl cations has been developed. It is
the first example where AIs serve as the [C,O] 2-atom synthon in organic
synthesis. This work not only reveals a new role of isatin AIs in
cycloaddition reaction but also provides an efficient access to unprecedented
spiroheterocycle compounds.
A Cs2CO3-mediated formal [4+3] cycloaddition involving benzofuran-derived azadienes (BDAs) and α‑bromohydroxamates to afford benzofuran-fused 1,4-diazepinones is established. This is the first example of using BDAs for the construction of seven-membered...
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