Purpose/Objective(s): Published data for post-operative radiation therapy (PORT) for patients with nonsmall cell lung cancer (NSCLC) treated with sublobar resections are limited. The purpose of this study is to investigate the association between PORT and survival for such patients. Materials/Methods: The 17-registry Survival, Epidemiology, and End Results (SEER) database was searched for patients with stage II or III NSCLC diagnosed between 1988 and 2003 and treated with sublobar resections. Only patients coded as receiving PORT or not receiving radiotherapy were included. Patients with prior malignancies were excluded. Patients with survival of less than 4 months were excluded to reduce selection bias favoring PORT. The inclusion criteria identified 958 patients. The median follow-up time was 5.2 years for patients still alive. Results: Predictors of PORT were identified. The 5 year overall survival rates with and without PORT were 17% and 20% (p = 0.076) respectively for the entire cohort, 13% and 13% (p = 0.093) respectively for patients with N2 disease, and 15% and 0 (p = 0.011) respectively for patients with tumor size .5cm. For patients with tumor size .5cm, PORT was associated with improved survival (p = .048). On univariate analysis, PORT was associated with inferior survival for the entire cohort. On multivariate analysis, PORT was not associated with survival for the entire cohort, patients with N2 nodal disease, or tumors .5cm. Conclusions: No survival benefit of PORT was demonstrated for the cohort as a whole, or for patients with N2 nodal disease. A possible survival benefit of PORT is suggested for patients with larger tumors treated with sublobar resections.Purpose/Objective(s): To observe the incidence of radiation pneumonitis (RP) in NSCLC and esophageal carcinoma treatment using three-dimensional conformal radiation therapy (3DCRT) and obtain important predictors. Materials/Methods: From patients with locally advanced NSCLC or esophageal carcinoma received 3DCRT. There were 53 patients with NSCLC, the prescription dose was 60Gy/30-34fx, all of them received concurrent chemotherapy of navelbine+cisplatin. There were 108 patients with esophageal carcinomas received irradiation of 58-70Gy/29-35fx, 46 of them received 3DCRT only, 62 of them received concurrent chemotherapy of calcium folinate +5-Fu +cisplatin. Results: The overall incidence rate of RP was 57.8%. For the patients with NSCLC, 94%developed RP (grade 1 for 22 patients, grade 2 for 18 patients , grade 3 for 8 patients , grade 4 for 1 and grade 5 for 1 patients), for the patients with esophageal carcinoma, 39.8% developed RP (grade 1 for 21 patients, grade 2 for 15 patients and grade 3 for 7 patients). The correlative factors included the sex of patients, the volume of GTV, mean lung dose , V 5 , V 10 , V 15 , V 20 ,V 25 and V 30 of normal lung according to Spearman correlative analysis, all the 9 factors could predict RP according to univariate analysis. Only V 5 and the volume of GTV were found independently associated with RP accordin...