Objective The purpose of this study was to compare the results of the three food-cue paradigms most commonly used for functional neuroimaging studies to determine: i) commonalities and differences in the neural response patterns by paradigm; and, ii) the relative robustness and reliability of responses to each paradigm. Design and Methods functional magnetic resonance imaging (fMRI) studies using standardized stereotactic coordinates to report brain responses to food cues were identified using on-line databases. Studies were grouped by food-cue modality as: i) tastes (8 studies); ii) odors (8 studies); and, iii) images (11 studies). Activation likelihood estimation (ALE) was used to identify statistically reliable regional responses within each stimulation paradigm. Results Brain response distributions were distinctly different for the three stimulation modalities, corresponding to known differences in location of the respective primary and associative cortices. Visual stimulation induced the most robust and extensive responses. The left anterior insula was the only brain region reliably responding to all three stimulus categories. Conclusions These findings suggest visual food-cue paradigm as promising candidate for imaging studies addressing the neural substrate of therapeutic interventions.

The assumption that the Universe, on sufficiently large scales, is homogeneous and isotropic is crucial to our current understanding of cosmology. In this paper we test if the observed galaxy distribution is actually homogeneous on large scales. We have carried out a multifractal analysis of the galaxy distribution in a volume limited subsample from the SDSS DR6. This considers the scaling properties of different moments of galaxy number counts in spheres of varying radius $r$ centered on galaxies. This analysis gives the spectrum of generalized dimension $D_q(r)$, where $q >0$ quantifies the scaling properties in overdense regions and $q<0$ in underdense regions. We expect $D_q(r)=3$ for a homogeneous, random point distribution. In our analysis we have determined $D_q(r)$ in the range $-4 \le q \le 4$ and $7 \le r \le 98 h^{-1} {\rm Mpc}$. In addition to the SDSS data we have analysed several random samples which are homogeneous by construction. Simulated galaxy samples generated from dark matter N-body simulations and the Millennium Run were also analysed. The SDSS data is considered to be homogeneous if the measured $D_q$ is consistent with that of the random samples. We find that the galaxy distribution becomes homogeneous at a length-scale between 60 and $70 h^{-1} {\rm Mpc}$. The galaxy distribution, we find, is homogeneous at length-scales greater than $70 h^{-1} {\rm Mpc}$. This is consistent with earlier works which find the transition to homogeneity at around $70 h^{-1} {\rm Mpc}$.Comment: 6 pages, 3 figures, Submitted for publicatio

Using Shapefinders, which are ratios of Minkowski functionals, we study the morphology of neutral hydrogen (HI) density fields, simulated using semi-numerical technique (inside-out), at various stages of reionization. Accompanying the Shapefinders, we also employ the 'largest cluster statistic' (LCS), originally proposed in Klypin & Shandarin (1993), to study the percolation in both neutral and ionized hydrogen. We find that the largest ionized region is percolating below the neutral fraction x HI 0.728 (or equivalently z 9). The study of Shapefinders reveals that the largest ionized region starts to become highly filamentary with non-trivial topology near the percolation transition. During the percolation transition, the first two Shapefinders -'thickness' (T ) and 'breadth' (B) -of the largest ionized region do not vary much, while the third Shapefinder -'length' (L) -abruptly increases. Consequently, the largest ionized region tends to be highly filamentary and topologically quite complex. The product of the first two Shapefinders, T ×B, provides a measure of the 'cross-section' of a filament-like ionized region. We find that, near percolation, the value of T × B for the largest ionized region remains stable at ∼ 7 Mpc 2 (in comoving scale) while its length increases with time. Interestingly all large ionized regions have similar cross-sections. However, their length shows a power-law dependence on their volume, L ∝ V 0.72 , at the onset of percolation.

Lineages of the generalist hemipteran herbivore Myzus persicae (green peach aphid) that have expanded their host range to include tobacco often have elevated nicotine tolerance. The tobacco-adapted M. persicae lineage used in this study was able to reproduce on nicotine-containing artificial diets at concentrations that were 15-fold higher than those that were lethal to a non-adapted M. persicae lineage. Fecundity of the nicotine-tolerant M. persicae lineage was increased by 100 μM nicotine in artificial diet, suggesting that this otherwise toxic alkaloid can serve as a feeding stimulant at low concentrations. This lineage also was pre-adapted to growth on tobacco, exhibiting no drop in fecundity when it was moved onto tobacco from a different host plant. Although growth of the non-tobacco-adapted M. persicae lineage improved after three generations on tobacco, this higher reproductive rate was not associated with increased nicotine tolerance. M. persicae gene expression microarrays were used to identify transcripts that are up-regulated in response to nicotine in the tobacco-adapted lineage. Induced expression was found for CYP6CY3, which detoxifies nicotine in M. persicae, other genes encoding known classes of detoxifying enzymes, as well as genes encoding secreted M. persicae salivary proteins.