Invasive breast cancer is a histologically heterogeneous disease; among numerous histological types, invasive ductal carcinoma (IDC) is the most common, present in 70%-75% of the cases (1, 2), followed by invasive lobular carcinoma (ILC), present in 5%-15% of the cases (1-3). Mixed invasive ductal and lobular carcinoma (IDLC), which has characteristics of both invasive ductal and lobular carcinoma, is present in approximately 5% of the cases (2). Lately, the prevalence of the lobular breast tumors has been on the rise, particularly in postmenopausal women; this increase has been linked with evidence suggesting that frequent use of hormone replacement therapy in recent years has increased the risk of ILC and IDLC development more than that of IDC (4-6). Clinicopathological characteristics and survival outcomes of ILC and IDC have been compared in numerous studies with conflicting results. On the other hand, few studies have compared IDLC with ILC and IDC. In this study, we compared ILC, IDC and IDLC in terms of clinicopathological and treatment features, metastatic patterns and longterm survival retrospectively in a 10 years patient cohort. Materials and Methods Ethical standards The research protocol of this clinical study was approved by the Ethics Committee of the
Objectives:To evaluate the efficacy of the Breast lesion excision system (BLES) procedure as a primary excisional biopsy for the management of breast imaging-reporting and data system (BI-RADS) category 3, small, and solid breast lesions in women having severe breast cancer anxiety.Methods:A retospective study was conducted on 68 patients who underwent a BLES procedure. The study protocol was approved by the local ethical committee of Yeni Yuzyıl University in Istanbul, Turkey. The study was carried out according to the principles of the Helsinki Declaration. Small breast lesions removed using a (12, 15 or 20 mm) wand from September 2011 to November 2014. These were category 3 lesions as determined by ultrasound (US) imaging according to BI-RADS. The radiological and pathological sizes of these lesions, the complete excision rates, the procedure durations, the pathological diagnosis, the complications, and the imaging findings before and after the procedure were all recorded.Results:All the patients had a benign pathology. The mean duration of procedure was 12 (range=8-22) minutes. There was no major complication during the procedure and in the following period. Only some small hematomas were determined in 3 (4.2%) patients, and no additional surgical intervention was performed.Conclusion:The BLES procedure is an optimal solution for the management of indeterminate BI-RADS category 3 breast lesions in women with severe anxiety.
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