There was no difference in the proportion of patients discharged early despite more patients being classified as low risk by the EDACS-ADP than the ADAPT-ADP. Both accelerated diagnostic pathways are effective strategies for chest pain assessment and resulted in an increased rate of early discharges compared with previously reported rates.
We propose a theoretical idea to use an ultracold Fermi gas as a quantum simulator for the study of the low-density region of a neutron-star interior. Our idea is different from the standard quantum simulator that heads for perfect replication of another system, such as the Hubbard model discussed in high-T c cuprates. Instead, we use the similarity between two systems and theoretically make up for the difference between them. That is, (1) we first show that the strong-coupling theory developed by Nozières and Schmitt-Rink (NSR) can quantitatively explain the recent experiment on the equation of state (EoS) in a 6 Li superfluid Fermi gas in the BCS (Bardeen-CooperSchrieffer) unitary limit far below the superfluid phase-transition temperature T c . This region is considered to be very similar to the low-density region (crust regime) of a neutron star (where a nearly unitary s-wave neutron superfluid is expected). (2) We then theoretically compensate the difference that, while the effective range r eff is negligibly small in a superfluid 6 Li Fermi gas, it cannot be ignored (r eff = 2.7 fm) in a neutron star, by extending the NSR theory to include effects of r eff . The calculated EoS when r eff = 2.7 fm is shown to agree well with the previous neutron-star EoS in the low-density region predicted in nuclear physics. Our idea indicates that an ultracold atomic gas may more flexibly be used as a quantum simulator for the study of other complicated quantum many-body systems, when we use not only the experimental high tunability, but also the recent theoretical development in this field. Since it is difficult to directly observe a neutron-star interior, our idea would provide a useful approach to the exploration for this mysterious astronomical object.
We theoretically present an economical and convenient way to study ground-state properties of a strongly interacting superfluid Fermi gas. Our strategy is that complicated strong-coupling calculations are used only to evaluate quantum fluctuation corrections to the chemical potential µ.Then, without any further strong-coupling calculations, we calculate the compressibility, sound velocity, internal energy, pressure, and Tan's contact, from the calculated µ without loss of accuracy, by using exact thermodynamic identities. Using a recent precise measurement of µ in a superfluid 6 Li Fermi gas, we show that an extended T -matrix approximation (ETMA) is suitable for our purpose, especially in the BCS-unitary regime, where our results indicate that many-body corrections are dominated by superfluid fluctuations. Since precise determinations of physical quantities are not always easy in cold Fermi gas physics, our approach would greatly reduce experimental and theoretical efforts toward the understanding of ground-state properties of this strongly interacting Fermi system.
In vivo bioconjugation to the free thiol on Cys34 of serum albumin by a strategically placed reactive group on a bioactive peptide is a useful tool to extend plasma half-life. Three maleimido derivates of human GH-releasing factor (hGRF)(1-29) were synthesized and bioconjugated to human serum albumin ex vivo. All three human serum albumin conjugates showed enhanced in vitro stability against dipeptidylpeptidase-IV and were bioactive in a GH secretion assay in cultured rat anterior pituitary cells. When the maleimido derivatives were individually administered sc to normal male Sprague Dawley rats, an acute secretion of GH was measured in plasma. The best compound, CJC-1295, showed a 4-fold increase in GH area under the curve over a 2-h period compared with hGRF(1-29). CJC-1295, a tetrasubstituted form of hGRF(1-29) with an added N epsilon-3-maleimidopropionamide derivative of lysine at the C terminus, was selected for further pharmacokinetic evaluation, where it was found to be present in plasma beyond 72 h. A Western blot analysis of the plasma of a rat injected with CJC-1295 showed the presence of a CJC-1295 immunoreactive species on the band corresponding to serum albumin, appearing after 15 min and remaining in circulation beyond 24 h. These results led to the identification of CJC-1295 as a stable and active hGRF(1-29) analog with an extended plasma half-life.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.