Strukturelle „Valid“‐ierung: Der Mechanismus des enzymkatalysierten konfigurationserhaltenden Glycosyltransfers gibt Rätsel auf, zumal aussagekräftige 3D‐Strukturen ternärer Inhibitor‐Enzym‐Komplexe fehlen. Durch die Synthese und mehrdimensionale kinetische Analyse von Validoxylaminderivaten wurde die 3D‐Struktur eines ternären Komplexes erhalten (siehe Bild; U=Uridyl), der Einblick in die Geometrie und das Donor‐Akzeptor‐Wechselspiel am Glycosyltransferzentrum gibt.
Structural “valid”‐ation: The mechanism of enzyme‐catalyzed glycosyl transfer with retention of anomeric configuration continues to baffle, a situation compounded by the lack of insightful 3‐D structures of ternary enzyme complexes. Synthesis and multi‐dimensional kinetic analysis of validoxylamine derivatives are used to access the 3‐D structure of a ternary complex (see picture; U=uridyl) providing insight into the geometry and donor–acceptor interplay at the glycosyltransfer site.
Seed germination and early seedling development are essential events in the plant life cycle that are controlled largely by the interplay and cross-talk between several plant hormones. Recently, major progress has been achieved in the elucidation at the molecular level of the signalling of these phytohormones. In this review, we summarise the data for the most promising classes of compounds, which could find potential agronomic applications for promoting seed germination and early seedling development even under abiotic stress conditions. Structural modifications of plant hormones are required to improve their biological performance and their specificity to allow commercial application.
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