Inorganic-organic hybrid materials such as organically templated metal oxides, metal-organic frameworks (MOFs) and organohalide perovskites have been studied for decades, and hydrothermal and (non-aqueous) solvothermal syntheses have produced thousands of new materials that collectively contain nearly all the metals in the periodic table. Nevertheless, the formation of these compounds is not fully understood, and development of new compounds relies primarily on exploratory syntheses. Simulation- and data-driven approaches (promoted by efforts such as the Materials Genome Initiative) provide an alternative to experimental trial-and-error. Three major strategies are: simulation-based predictions of physical properties (for example, charge mobility, photovoltaic properties, gas adsorption capacity or lithium-ion intercalation) to identify promising target candidates for synthetic efforts; determination of the structure-property relationship from large bodies of experimental data, enabled by integration with high-throughput synthesis and measurement tools; and clustering on the basis of similar crystallographic structure (for example, zeolite structure classification or gas adsorption properties). Here we demonstrate an alternative approach that uses machine-learning algorithms trained on reaction data to predict reaction outcomes for the crystallization of templated vanadium selenites. We used information on 'dark' reactions--failed or unsuccessful hydrothermal syntheses--collected from archived laboratory notebooks from our laboratory, and added physicochemical property descriptions to the raw notebook information using cheminformatics techniques. We used the resulting data to train a machine-learning model to predict reaction success. When carrying out hydrothermal synthesis experiments using previously untested, commercially available organic building blocks, our machine-learning model outperformed traditional human strategies, and successfully predicted conditions for new organically templated inorganic product formation with a success rate of 89 per cent. Inverting the machine-learning model reveals new hypotheses regarding the conditions for successful product formation.

Data-trained predictive models see widespread use, but for the most part they are used as black boxes which output a prediction or score. It is therefore hard to acquire a deeper understanding of model behavior, and in particular how different features influence the model prediction. This is important when interpreting the behavior of complex models, or asserting that certain problematic attributes (like race or gender) are not unduly influencing decisions.In this paper, we present a technique for auditing black-box models, which lets us study the extent to which existing models take advantage of particular features in the dataset, without knowing how the models work. Our work focuses on the problem of indirect influence: how some features might indirectly influence outcomes via other, related features. As a result, we can find attribute influences even in cases where, upon further direct examination of the model, the attribute is not referred to by the model at all.Our approach does not require the black-box model to be retrained. This is important if (for example) the model is only accessible via an API, and contrasts our work with other methods that investigate feature influence like feature selection. We present experimental evidence for the effectiveness of our procedure using a variety of publicly available datasets and models. We also validate our procedure using techniques from interpretable learning and feature selection, as well as against other black-box auditing procedures.

Abstract-Data-trained predictive models see widespread use, but for the most part they are used as black boxes which output a prediction or score. It is therefore hard to acquire a deeper understanding of model behavior, and in particular how different features influence the model prediction. This is important when interpreting the behavior of complex models, or asserting that certain problematic attributes (like race or gender) are not unduly influencing decisions.In this paper, we present a technique for auditing black-box models, which lets us study the extent to which existing models take advantage of particular features in the dataset, without knowing how the models work. Our work focuses on the problem of indirect influence: how some features might indirectly influence outcomes via other, related features. As a result, we can find attribute influences even in cases where, upon further direct examination of the model, the attribute is not referred to by the model at all.Our approach does not require the black-box model to be retrained. This is important if (for example) the model is only accessible via an API, and contrasts our work with other methods that investigate feature influence like feature selection. We present experimental evidence for the effectiveness of our procedure using a variety of publicly available datasets and models. We also validate our procedure using techniques from interpretable learning and feature selection, as well as against other black-box auditing procedures.

The structural and electronic adaptability of a vanadium selenite framework is determined using cheminformatics data and machine learning algorithms.