The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms (SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were genome-wide significant in their relationship with adiponectin (P≤5×10−8). We then tested whether these 5 SNPs were associated with risk of T2D and CHD using a Bonferroni-corrected threshold of P≤0.011 to declare statistical significance for these disease associations. SNPs at the adiponectin-encoding ADIPOQ locus demonstrated the strongest associations with adiponectin levels (P-combined = 9.2×10−19 for lead SNP, rs266717, n = 14,733). A novel variant in the ARL15 (ADP-ribosylation factor-like 15) gene was associated with lower circulating levels of adiponectin (rs4311394-G, P-combined = 2.9×10−8, n = 14,733). This same risk allele at ARL15 was also associated with a higher risk of CHD (odds ratio [OR] = 1.12, P = 8.5×10−6, n = 22,421) more nominally, an increased risk of T2D (OR = 1.11, P = 3.2×10−3, n = 10,128), and several metabolic traits. Expression studies in humans indicated that ARL15 is well-expressed in skeletal muscle. These findings identify a novel protein, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk.

This literature review considers the use of action research in higher education. It specifically looks at two areas of higher education activity. The first concerns academic teaching practice and includes a discussion of research and pedagogy practice, and staff development. The second considers student engagement. In both these core features of higher education, action research has proved to be a central approach to the investigation, reflection and improvement of practice. Each of these main foci includes a discussion of the limitations of the literature. The review illustrates the extent and range of uses to have benefited from an action research approach.Keywords: higher education; action research, literature review; reflective practice 2 Literature Review on the Use of Action Research in Higher EducationThe centrality of students as fee paying customerts, besides based on the value of their fees, has focused UK Government policy in the higher education sector on the importance of the quality of teaching and rates of retention. On 1 July 2015, Jo Johnson, UK Minster for Higher Education, confirmed the second of his party's election pledges concerning teaching in higher education: secondly, delivering a teaching excellence framework that creates incentives for universities to devote as much attention to the quality of teaching as fee-paying students and prospective employers have a right to expect. (Johnson 2015) The justification for such a scheme is as follows:to meet students' high expectations of their university years and to deliver the skills our economy needs, we need a renewed focus on teaching. (ibid.)A process was put in motion that seeks to enact changes to put teaching at the heart of higher education policy. The extrinsic value of teaching, or its value for money, is thus established as a metric of the level of skill, inferred from its calculative value: as a professional activity -as a vocation -higher education is undermined. Whether this exposes the essence of higher education provision is contentious, but the rebalance of emphasis from research to teaching in our mass participation higher education system clearly has intrinsic merit, and certainly possesses political leverage. Amid the development of lecturers' capability to teach and facilitate learning is the enhancement of pedagogical practice through reflection and research into practice (Gibbs, Angelides and Michaelides 2004). In this context, the importance of action research (AR) as a method of revelation, instruction and improvement, and as the realisation of technical skill and facilitation of learning, is hard to overemphasise. Informed practice removes the consumeristic notion of lecturers as emotional labourers, intent on satisfying students' consumerist desires, and balances the edifying mission of higher education institutions. This literature review is undertaken to contribute to this aim. It attempts to reflect AR from a number of perspectives and to consider its implications and limitations in regard to generating the...

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. Dynamical systems theory describes how behaviours can deviate through a series of states (stable or unstable) before returning to an original stable state. It has been suggested that squash performance exhibits properties akin to a dynamical system and demonstrated that squash experts were able to reliably discriminate weak or strong shots that gave one player a distinct advantage over their opponent. They argued that experts were essentially identifying "perturbations" which they defined as incidents that change a system state from a stable to an unstable situation or vice versa. Similarly, in this paper we examine ball possession in soccer and consider those where neither team has a distinct advantage as being a stable situation and perturbation attempts as those where an effort is made to gain a distinct advantage. This study assessed the relative frequency and success rate of perturbation attempts in relation to the match status (match score at the time of the incident). A hand notation system was designed to record the variables of interest (players involved, pitch locations, behaviours performed and behaviour outcomes). Eight domestic league matches from the 2007/2008 season involving a Coca-Cola League One team were analysed. Results indicated that the home team made significantly less perturbation attempts (11.78% of total possessions) compared to the away teams (17.54%) but that generally perturbation attempts were more likely to be unsuccessful than successful (Z = 2.37, p < 0.05). Future studies need to assess if the frequency of perturbation attempts and perturbation success rates are related to playing standard.