To facilitate continued direct intrathrombus infusion of a thrombolytic agent and yet minimize catheter exchanges and manipulations, the authors developed a simple, self-contained delivery system. It involves the use of supplies available in most angiographic suites. The system has been used in 44 patients; there have been no infectious complications, and it has been well tolerated by the patients.
This regimen is active in patients with metastatic melanoma and renal cell carcinoma and produces meaningful responses in a small percentage of these patients; however, it is not clear whether cyclophosphamide, doxorubicin, and IFN alpha-2a as used in this protocol appreciably augmented the antitumor activity of the IL-2-LAK cell regimen.
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