Few studies have addressed the etiology and clinical outcomes of community-acquired pneumonia (CAP) treated in an ambulatory setting. We investigated the etiology by the culture of Mycoplasma pneumoniae, urine antigen testing of Streptococcus pneumoniae and Legionella pneumoniae, and DNA or RNA determination of eight kinds of respiratory virus DNA or RNA. An etiological diagnosis was made in 51.8% of 197 patients. The most common pathogens were M. pneumoniae (29.4%) followed by influenza virus A, parainfluenza virus, adenovirus, human metapneumovirus (9.6%), and S. pneumoniae (4.1%). Patients with mycoplasma infections were younger, less likely to have comorbidities, and less likely to have adequate sputum for gram stain and culture. Patients with viral infections were older and more likely to have poorly defined nodules on chest X-ray (CXR) or computed tomography (CT) scan. Among patients infected with M. pneumoniae, those with quinolones as initial prescriptions had shorter duration of fever after the initiation of antibiotics than patients with β-lactams, macrolides, or β-lactams + macrolides (p < 0.05). This study suggests that M. pneumoniae and respiratory viruses were the most frequent pathogens found in ambulatory adult CAP patients and quinolones were better than β-lactams, macrolides, or β-lactams + macrolides in the resolution of fever of M. pneumoniae pneumonia.

Further improvement of optoelectronic performance is a target for all-inorganic lead halide perovskite material CsPbBr3; however, it is greatly limited by the quality of the material which is dominated to some extent by defects, especially intrinsic point defects. In this study, the intrinsic point defects in melt-grown CsPbBr3 crystals were studied by thermally stimulated current technology and the simultaneous multiple peak analysis (SIMPA) method. The defect formation mechanism was analyzed systematically by combining the SIMPA fitting results with defect-related parameters, material properties, and external conditions. The main analytical defects, VCs and VBr vacancies, Csi and Pbi interstitials, and PbBr antisites, matched up with theoretical prediction well. Such systematic studies of defect types and concentration give us more insights into the carrier transport mechanism of CsPbBr3 and will help us find ways to improve the crystal quality by controlling the types and concentration of point defects.

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