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Background: Good general well-being of nurses is associated with reduced burnout and improved patient safety. However, few studies explored the factors of nurses' general well-being. Aim:The study aimed to assess general well-being and its predictors among hospital nurses. Methods:The study recruited 573 nurses working in a tertiary Chinese hospital to complete a survey of sociodemographic characteristics, DiSC ® personality profile, Self-Rating Anxiety Scale and general well-being. Multivariate linear regression was conducted to assess factors affecting nurses' general well-being.Results: Marital status and clinical rank had a positive impact on general well-being, especially when nurses were married or in the stage of assistant nursing manager.Conversely, source of stress, DiSC ® profile and SAS score had a negative effect on general well-being, especially when nurses' stress came from colleagues, nurses were characterized by steadiness and conscientiousness, and nurses had extreme anxiety. Conclusion: Marital status, clinical rank, source of stress, DiSC ® profile and SAS score were main factors affecting hospital nurses' general well-being. Implications for Nursing Management: By giving careful attention to nurses' family life, career development, personality characteristics and applying appropriate interventions, nursing managers can improve general well-being of nurses and promote patient care. K E Y W O R D S anxiety, general well-being, nurses, personality | 541 YU et al.

Purpose: For many tumors, signaling exchanges between cancer cells and other cells in their microenvironment influence overall tumor signaling. Some of these exchanges depend on expression of the primary cilium on nontransformed cell populations, as extracellular ligands including Sonic Hedgehog (SHH), PDGFRa, and others function through receptors spatially localized to cilia. Cell ciliation is regulated by proteins that are themselves therapeutic targets. We investigated whether kinase inhibitors of clinical interest influence ciliation and signaling by proteins with ciliary receptors in cancer and other cilia-relevant disorders, such as polycystic kidney disease (PKD).Experimental Design: We screened a library of clinical and preclinical kinase inhibitors, identifying drugs that either prevented or induced ciliary disassembly. Specific bioactive protein targets of the drugs were identified by mRNA depletion. Mechanism of action was defined, and activity of select compounds investigated.Results: We identified multiple kinase inhibitors not previously linked to control of ciliation, including sunitinib, erlotinib, and an inhibitor of the innate immune pathway kinase, IRAK4. For all compounds, activity was mediated through regulation of Aurora-A (AURKA) activity. Drugs targeting cilia influenced proximal cellular responses to SHH and PDGFRa. In vivo, sunitinib durably limited ciliation and ciliarelated biological activities in renal cells, renal carcinoma cells, and PKD cysts. Extended analysis of IRAK4 defined a subset of innate immune signaling effectors potently affecting ciliation.Conclusions: These results suggest a paradigm by which targeted drugs may have unexpected off-target effects in heterogeneous cell populations in vivo via control of a physical platform for receipt of extracellular ligands. Conception and design: A.A. Kiseleva, V.A. Korobeynikov, E.A. Golemis Development of methodology: V.A. Korobeynikov, P. Makhov Acquisition of data (provided animals, acquired and managed patients, provided facilities, etc.): A.A. Kiseleva, V.A. Korobeynikov, A.S. Nikonova, P. Zhang, M.B. Einarson Analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis): A.A.