Light‐assisted antibacterial therapy is a promising alternative to antibiotic therapy due to the high antibacterial efficacy without bacterial resistance. Recent research has mainly focused on the use of near‐infrared light irradiation to kill bacteria by taking advantage of the synergistic effects rendered by hyperthermia and radical oxygen species. However, photocatalytic antibacterial therapy excited by visible light is more convenient and practical, especially for wounds. Herein, a visible light responsive organic‐inorganic hybrid of ZnTCPP/Ti3C2TX is designed and fabricated to treat bacterial infection with antibacterial efficiency of 99.86% and 99.92% within 10 min against Staphylococcus aureus and Escherichia coli, respectively. The porphyrin‐metal complex, ZnTCPP, is assembled on the surface of Ti3C2TX MXene to capture bacteria electrostatically and the Schottky junction formed between Ti3C2TX and ZnTCPP promotes visible light utilization, accelerates charge separation, and enhances the mobility of photogenerated charges, and finally increases the photocatalytic activity. As a result of the excellent bacteria capturing ability and photocatalytic antibacterial effects, ZnTCPP/Ti3C2TX exposed to visible light has excellent antibacterial properties in vitro and in vivo. Therefore, organic‐inorganic materials that have been demonstrated to possess good biocompatibility and enhance wound healing have large potential in bio‐photocatalysis, antibacterial therapy, as well as antibiotics‐free treatment of wounds.

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