Motivation: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze gene expression profiles. These exploratory feature extraction techniques yield expression modes (ICA) or metagenes (NMF). These extracted features are considered indicative of underlying regulatory processes. They can as well be applied to the classification of gene expression datasets by grouping samples into different categories for diagnostic purposes or group genes into functional categories for further investigation of related metabolic pathways and regulatory networks. Results: In this study we focus on unsupervised matrix factorization techniques and apply ICA and sparse NMF to microarray datasets. The latter monitor the gene expression levels of human peripheral blood cells during differentiation from monocytes to macrophages. We show that these tools are able to identify relevant signatures in the deduced component matrices and extract informative sets of marker genes from these gene expression profiles. The methods rely on the joint discriminative power of a set of marker genes rather than on single marker genes. With these sets of marker genes, corroborated by leave-one-out or random forest cross-validation, the datasets could easily be classified into related diagnostic categories. The latter correspond to either monocytes versus macrophages or healthy vs Niemann Pick C disease patients.
El acceso a la versión del editor puede requerir la suscripción del recurso Access to the published version may require subscription AbstractThis paper evaluates the performance of the twelve primary systems submitted to the evaluation on speaker verification in the context of a mobile environment using the MOBIO database. The mobile environment provides a challenging and realistic test-bed for current state-of-the-art speaker verification techniques. Results in terms of equal error rate (EER), half total error rate (HTER) and detection error trade-off (DET) confirm that the best performing systems are based on total variability modeling, and are the fusion of several sub-systems. Nevertheless, the good old UBM-GMM based systems are still competitive. The results also show that the use of additional data for training as well as gender-dependent features can be helpful.
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