Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms.
Abstract:In order to safeguard the material and immaterial heritage and to foster delightful experiences for visitors, this investigation aimed to define a Matrix of Priorities for management of Visitation Impacts Management on the Geosites of Araripe UNESCO Global Geopark. With a quantitative approach involving the revision of documents, the methods used in this paper determined what the demands for visitation are as well as the impacts of these demands. We identified the offers for activities and occurrences in the geosites. Using this model, we calculated the following variables: (i) evident impacts, (ii) management profile, (iii) visitor demand and (iv) activity zone. We also classified the recommended management actions and presented the priority matrix. We classified the geosites of Ponte de Pedra, Riacho do Meio and Cachoeira de Missão Velha as requiring immediate or priority management action, in view of the high impacts of visitation evidenced. The geosites of Pedra Cariri, Floresta Petrificada and Parque dos Pterossauros were classified as programmed action, highlighting the difficulty of accessing them and the low demand for visitation. The geosites Pontal de Santa Cruz, Colina do Horto and Batateiras presented the best scores and require feedback action. It is emphasized that the deepening the investigations is required
In this investigation, we formulated the Ecosystem’s Health Provision Spectrum and its centrality indicators, based on the identification of the Ecosystem Health Potentials and Opportunities on the trails of Santo Sepulcro and Riacho do Meio in the Araripe UNESCO Global Geopark (UGG), establishing a baseline for the promotion of green exercise and geotourism in the territory. Based on the network methodology for complex systems, we analyzed the closeness and strength of biotic, abiotic variables, nature phenomena, infrastructure, and sensory experiences in order to determine the configuration of these associations. In the Santo Sepulcro, regarding the association, two negative relations and two positive relations among the variables were highlighted; as for closeness and strength, Aquatic Diversity with the Scientific Values of Geodiversity stood out. In Riacho do Meio, we highlight three positive associations among the variables; as for connectivity, Biodiversity and Meteorological and Climate Exposure presented the highest values and, as for strength, the variables Biodiversity, Route Classification, and Aquatic Diversity were the most prominent. We conclude, based on the presented configuration, that the variables with greater connectivity act as hubs; if these variables are optimized, the network will present an acceptable theoretical configuration. However, neglecting central strength variables can cause the network to collapse.
Este estudo investigou como as medidas de distanciamento social para o combate ao COVID-19 tem influenciado o nível de atividade física. Um questionário estruturado sobre as práticas de atividade física antes e durante o período de distanciamento social foi disponibilizado on-line para coleta das informações dos 2004 adultos (18 anos ou mais de idade) residentes em municípios das cinco regiões brasileiras. Utilizou-se teste Qui-quadrado para avaliar associações entre o nível de atividade física anterior e durante o período da pandemia. Associações entre variáveis intervenientes foram verificadas através do odds ratio. Os participantes reduziram o nível de atividade física após a adoção das medidas de distanciamento social. O maior nível de atividade física durante a pandemia está associado ao sexo masculino, residir em região metropolitana e não pertencer a grupos de risco. Embora estes fatores já influenciassem o nível de atividade física antes da pandemia, os resultados do odds ratio indicaram que no período da pandemia os fatores sexo, região e risco apresentaram reduções no seu poder de predição. Questões levantadas neste estudo podem auxiliar o planejamento de ações voltadas ao incentivo da prática de atividade física em períodos de crise.
Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3.
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